Document Detail

In-vivo Efficacy of Apramycin in Murine Infection Models.
MedLine Citation:
PMID:  25136009     Owner:  NLM     Status:  Publisher    
Apramycin is a unique aminoglycoside with a dissociation of antibacterial activity and ototoxicity. We assessed the antibacterial efficacy of apramycin in two murine models of infection: Mycobacterium tuberculosis aerosol infection and Staphlyococcus aureus septicaemia. In both infection models the efficacy of apramycin was comparable to that of amikacin. These results suggest that apramycin has the potential to become a clinically useful agent against drug resistant pathogens and support further development of this promising unique aminoglycoside.
Martin Meyer; Pietro Freihofer; Michael Scherman; Joanne Teague; Anne Lenaerts; Erik C Böttger
Related Documents :
24965469 - Impaired nef function is associated with early control of hiv-1 viremia.
24282589 - Preliminary insights into the impact of dietary starch on the ciliate, neobalantidium c...
22972359 - Protective effect of azadirachta indica extract against eimeria papillata-induced cocci...
24060549 - The syphilis epidemics in hungary 1985-2004, before entering the european union.
23192499 - A study on the association between parvovirus b19 infection, serum tumour necrosis fact...
25201409 - Helminths in the lungs.
2565919 - Isolation and purification of scrapie-associated fibrils and prion protein from scrapie...
22436459 - Batrachochytrium dendrobatidis infection of amphibians in the doñana national park, spa...
22184209 - Haemophilia-associated yersinia pseudotuberculosis serotype o:1 septicaemia: the role o...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-18
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  -     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Identification and characterization of linezolid-resistant USA300 Staphylococcus aureus isolates fro...
Next Document:  Role of PBPD1 in stimulation of Listeria monocytogenes biofilm formation by sub-minimal inhibitory ?...