Document Detail


In-vivo Efficacy of Apramycin in Murine Infection Models.
MedLine Citation:
PMID:  25136009     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Apramycin is a unique aminoglycoside with a dissociation of antibacterial activity and ototoxicity. We assessed the antibacterial efficacy of apramycin in two murine models of infection: Mycobacterium tuberculosis aerosol infection and Staphlyococcus aureus septicaemia. In both infection models the efficacy of apramycin was comparable to that of amikacin. These results suggest that apramycin has the potential to become a clinically useful agent against drug resistant pathogens and support further development of this promising unique aminoglycoside.
Authors:
Martin Meyer; Pietro Freihofer; Michael Scherman; Joanne Teague; Anne Lenaerts; Erik C Böttger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-18
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  -     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
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