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In vivo Detection of Cortical Microinfarcts on Ultrahigh-Field MRI.
MedLine Citation:
PMID:  22607584     Owner:  NLM     Status:  Publisher    
BACKGROUND AND PURPOSE: Cortical microinfarcts (CMIs) are detected as small foci restricted to the cerebral cortex in autopsy brains. CMIs are thought to be caused by cerebral amyloid angiopathy (CAA) in the elderly and may be a risk for dementia. We aimed to visualize CMIs, which remain invisible on conventional MRI, using double inversion recovery (DIR) and 3-dimensional fluid attenuated inversion recovery (3D-FLAIR) on 3-Tesla MRI. METHODS: We prospectively performed DIR and 3D-FLAIR images in 70 subjects with Alzheimer disease (AD; n = 47), mild cognitive impairment (n = 14), AD with cerebrovascular disease (CVD; n = 3), vascular dementia (VaD; n = 2), CAA-associated intracerebral hemorrhage (ICH; n = 2) and one each of normal pressure hydrocephalus and dementia with Lewy bodies (DLB). Susceptibility-weighted imaging (SWI) was performed to detect cerebral microbleeds (CMBs). RESULTS: Nine subjects (five of AD and one each of AD with CVD, ICH, VaD, and DLB) had small intracortical high signal lesions on both DIR and 3D-FLAIR images. All the nine subjects accompanied multiple lobar CMBs. These intracortical lesions were located in close proximity to CMBs, and were suggested to be CMIs. CONCLUSIONS: DIR and 3D-FLAIR images may open a way to visualize CMIs. J Neuroimaging 2012;XX:1-5.
Yuichiro Ii; Masayuki Maeda; Hirotaka Kida; Ko Matsuo; Akihiro Shindo; Akira Taniguchi; Hidekazu Tomimoto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-18
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  -     ISSN:  1552-6569     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 by the American Society of Neuroimaging.
From the Department of Neurology (YI, KM, AS, AT, HT); Department of Radiology (MM); and Dementia Prevention and Therapeutic (HK), Mie University Graduate School of Medicine, Mie, Japan.
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