Document Detail


In vivo assessment of neurocardiovascular regulation in the mouse: principles, progress, and prospects.
MedLine Citation:
PMID:  21705676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A growing body of evidence indicates that a number of common complex diseases, including hypertension, heart failure, and obesity, are characterized by alterations in central neurocardiovascular regulation. However, our understanding of how changes within the central nervous system contribute to the development and progression of these and other diseases remains unclear. As with many areas of cardiovascular research, the mouse has emerged as a key species for investigations of neuroregulatory processes because of its amenability to highly specific genetic manipulations. In parallel with the development of increasingly sophisticated murine models has come the miniaturization and advancement in methodologies for in vivo assessment of neurocardiovascular end points in the mouse. The following brief review will focus on a number of key direct and indirect experimental approaches currently in use, including measurement of arterial blood pressure, assessment of cardiovascular autonomic control, and evaluation of arterial baroreflex function. The advantages and limitations of each methodology are highlighted to allow for a critical evaluation by the reader when considering these approaches.
Authors:
Colin N Young; Robin L Davisson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-06-24
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  301     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-31     Completed Date:  2011-11-01     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H654-62     Citation Subset:  IM    
Affiliation:
Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA. cny2@cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Nervous System / physiopathology*
Baroreflex
Blood Pressure
Cardiovascular Diseases / diagnosis*,  genetics,  physiopathology
Cardiovascular System / innervation*
Central Nervous System / physiopathology*
Diagnostic Techniques, Cardiovascular* / instrumentation
Disease Models, Animal
Equipment Design
Mice
Mice, Transgenic
Miniaturization
Grant Support
ID/Acronym/Agency:
HL-63887/HL/NHLBI NIH HHS; HL-84624/HL/NHLBI NIH HHS; HL-96571/HL/NHLBI NIH HHS
Comments/Corrections

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