| In vivo 4.0-T magnetic resonance investigation of spinal cord inflammation, demyelination, and axonal damage in chronic-progressive experimental allergic encephalomyelitis. | |
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MedLine Citation:
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PMID: 15390226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To image and dissect the lumbar spinal cord of guinea pigs with chronic-progressive experimental allergic encephalomyelitis (CP-EAE) and directly correlate the pathology to the magnetic resonance (MR) image data obtained at 4 T and determine if these MR contrasts can accurately differentiate a specific type of pathology from control tissue. MATERIALS AND METHODS: The amount of inflammation, demyelination, and axonal pathology were quantified in the whole cord cross sections. The signal intensities (SIs) for 228 individual regions of interest (ROIs) (normal-appearing white matter (NAWM) and tissue containing inflammation with or without demyelination) were measured directly from the corresponding area on the MR images. RESULTS: Conventional MR contrast SIs and magnetization transfer ratio (MTR) were related to the degree of demyelination and presence of inflammation. MTR and proton density-weighted (PDw) SIs were both moderately related to axonal density. The SIs for NAWM and in lesions containing both cellular infiltrates and demyelination in all conventional MR contrast images were also increased, whereas the MTR was decreased when compared to control tissue. CONCLUSION: The SIs from the conventional MR contrasts and MTR at 4 T were sensitive to the presence of disease within CP-EAE spinal cord, but were not specific to the underlying pathology. |
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Authors:
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Lisa L Cook; Paula J Foster; J Ross Mitchell; Stephen J Karlik |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 20 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-29 Completed Date: 2005-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 563-71 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Physiology Department, University of Western Ontario, London, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Chi-Square Distribution Chronic Disease Encephalomyelitis, Autoimmune, Experimental / pathology* Female Guinea Pigs Inflammation / pathology Lumbosacral Region Magnetic Resonance Imaging / methods* ROC Curve Spinal Cord / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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