Document Detail


In vivo 3-dimensional Magnetic Resonance Wall Shear Stress Estimation in Ascending Aortic Dilatation.
MedLine Citation:
PMID:  21512609     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To estimate surface-based wall shear stress (WSS) and evaluate flow patterns in ascending aortic dilatation (AscAD) using a high-resolution, time-resolved, three-dimensional (3D), three-directional velocity encoded, radially undersampled phase contrast magnetic resonance sequence (4D PC-MRI). MATERIALS AND METHODS: 4D PC-MRI was performed in 11 patients with AscAD (46.3±22.0 years) and 10 healthy volunteers (32.9±13.4 years) after written informed consent and IRB-approval. Following manual vessel wall segmentation of the ascending aorta (MATLAB, The Mathworks, Natick, MA), a 3D surface was created using spline interpolation. Spatial WSS variation based on surface division in 12 segments and temporal variation were evaluated in AscAD and normal aortas. Visual analysis of flow patterns was performed based on streamlines and particle traces using EnSight (v9.0, CEI, Apex, NC). RESULTS: AscAD was associated with significantly increased diastolic WSS, decreased systolic to diastolic WSS ratio, and delayed onset of peak WSS (all P < 0.001). Temporally averaged WSS was increased and peak systolic WSS was decreased. The maximum WSS in AscAD was on the anterior wall of the ascending aorta. Vortical flow with highest velocities along the anterior wall and increased helical flow during diastole were observed in AscAD compared to controls. CONCLUSION: Changes in WSS in the ascending aorta of AscAD correspond to observed alterations in flow patterns compared to controls.
Authors:
Erik T Bieging; Alex Frydrychowicz; Benjamin R Landgraf; Kevin M Johnson; Oliver Wieben; Christopher J François
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  33     ISSN:  1522-2586     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-4-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  589-597     Citation Subset:  -    
Affiliation:
Department of Radiology, University of Wisconsin - Madison.
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Grant Support
ID/Acronym/Agency:
R01 HL072260-06//NHLBI NIH HHS

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