| In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism. | |
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MedLine Citation:
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PMID: 21185269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Attentional dysfunction is one of the most consistent findings in individuals with autism spectrum disorders (ASD). However, the significance of such findings for the pathophysiology of autism is unclear. In this study, we investigated cellular neurochemistry with proton magnetic resonance spectroscopy imaging ((1)H-MRS) in brain regions associated with networks subserving alerting, orienting, and executive control of attention in patients with ASD. Concentrations of cerebral N-acetyl-aspartate (NAA), creatinine+phosphocreatinine, choline-containing compounds, myo-inositol (Ins) and glutamate+glutamine (Glx) were determined by 3T (1)H-MRS examinations in 14 high-functioning medication-free adults with a diagnosis of ASD and 14 age- and IQ-matched healthy controls (HC) in the anterior cingulate cortex (ACC), thalamus, temporoparietal junction (TPJ), and areas near or along the intraparietal sulcus (IPS). Compared to HC group, the ASD group showed significantly lower Glx concentration in right ACC and reduced Ins concentration in left TPJ. This study provides evidence of abnormalities in neurotransmission related to networks subserving executive control and alerting of attention, functions which have been previously implicated in ASD pathogenesis. |
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Authors:
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Silvia Bernardi; Evdokia Anagnostou; Jun Shen; Alexander Kolevzon; Joseph D Buxbaum; Eric Hollander; Patrick R Hof; Jin Fan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-12-23 |
Journal Detail:
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Title: Brain research Volume: 1380 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-01 Completed Date: 2012-01-18 Revised Date: 2012-03-26 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 198-205 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Attention / physiology* Brain / anatomy & histology, metabolism, physiopathology* Brain Chemistry / physiology* Child Development Disorders, Pervasive / diagnosis*, physiopathology Female Humans Infant, Newborn Magnetic Resonance Spectroscopy / methods* Male Nerve Net / metabolism, physiopathology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000071/RR/NCRR NIH HHS; MH083164/MH/NIMH NIH HHS; R21 MH083164-01/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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