| In vitro validation of real-time three-dimensional color Doppler echocardiography for direct measurement of proximal isovelocity surface area in mitral regurgitation. | |
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MedLine Citation:
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PMID: 17493476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The 2-dimensional (2D) color Doppler (2D-CD) proximal isovelocity surface area (PISA) method assumes a hemispheric flow convergence zone to estimate transvalvular flow. Recently developed 3-dimensional (3D)-CD can directly visualize PISA shape and surface area without geometric assumptions. To validate a novel method to directly measure PISA using real-time 3D-CD echocardiography, a circulatory loop with an ultrasound imaging chamber was created to model mitral regurgitation (MR). Thirty-two different regurgitant flow conditions were tested using symmetric and asymmetric flow orifices. Three-dimensional-PISA was reconstructed from a hand-held real-time 3D-CD data set. Regurgitant volume was derived using both 2D-CD and 3D-CD PISA methods, and each was compared against a flow-meter standard. The circulatory loop achieved regurgitant volume within the clinical range of MR (11 to 84 ml). Three-dimensional-PISA geometry reflected the 2D geometry of the regurgitant orifice. Correlation between the 2D-PISA method regurgitant volume and actual regurgitant volume was significant (r(2) = 0.47, p <0.001). Mean 2D-PISA regurgitant volume underestimate was 19.1 +/- 25 ml (2 SDs). For the 3D-PISA method, correlation with actual regurgitant volume was significant (r(2) = 0.92, p <0.001), with a mean regurgitant volume underestimate of 2.7 +/- 10 ml (2 SDs). The 3D-PISA method showed less regurgitant volume underestimation for all orifice shapes and regurgitant volumes tested. In conclusion, in an in vitro model of MR, 3D-CD was used to directly measure PISA without geometric assumption. Compared with conventional 2D-PISA, regurgitant volume was more accurate when derived from 3D-PISA across symmetric and asymmetric orifices within a broad range of hemodynamic flow conditions. |
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Authors:
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Stephen H Little; Stephen R Igo; Bahar Pirat; Marti McCulloch; Craig J Hartley; Yukihiko Nosé; William A Zoghbi |
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Publication Detail:
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Type: Journal Article; Validation Studies Date: 2007-04-09 |
Journal Detail:
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Title: The American journal of cardiology Volume: 99 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-11 Completed Date: 2007-08-02 Revised Date: 2012-05-11 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1440-7 Citation Subset: AIM; IM |
Affiliation:
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Methodist DeBakey Heart Center, Houston, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity* Computer Systems* Echocardiography, Doppler, Color / methods* Echocardiography, Three-Dimensional / methods* Equipment Design Humans Image Interpretation, Computer-Assisted Image Processing, Computer-Assisted Linear Models Mitral Valve Insufficiency / physiopathology*, ultrasonography* Observer Variation Research Design |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL022512/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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Am J Cardiol. 2007 Nov 1;100(9):1495-6
[PMID:
17950817
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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