Document Detail


In vitro toxicity of halogenated anaesthetics on guineapig alveolar macrophages, surviving in gas phase.
MedLine Citation:
PMID:  6712857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential toxicity of halogenated anaesthetics on cellular immunity has been investigated on guineapig macrophages in gas phase by measuring the adenosine 5' triphosphate (ATP) concentration in the macrophages. A toxicity index (TI) was obtained by comparing the ATP concentration in vapour or gas-exposed macrophages with that of control cells. The TI for 5% halothane in air after 24 h was 31.2 +/- 8.3%. The TI for 5% enflurane in air was 12.7 +/- 6.6% (P less than 0.01). In an oxygen-enriched gas mixture (60%), the halothane TI increased to 65 +/- 6.6%, whereas that for enflurane remained at 15.4 +/- 16.9% (P less than 0.01). In macrophages exposed to 1% halothane, or 2% enflurane, in 50% nitrous oxide in oxygen, for 3 and 6 h, the halothane TI (0.4 +/- 3.3%) and the enflurane TI (2.5 +/- 4.1%) did not differ significant from the control group after 3 h. However, after 6 h exposure the halothane TI (31.3 +/- 9.6%) and the enflurane TI (17 +/- 20%) were different (P = 0.05) from control. It is concluded that the prolonged administration of high concentrations of halothane and enflurane alone decreased macrophages ATP concentration. A high concentration of oxygen in the gas mixture increased significantly the halothane TI.
Authors:
C Voisin; P A Scherpereel; C Aerts; D Lepot
Related Documents :
12552187 - Response surface modeling of remifentanil-propofol interaction on cardiorespiratory con...
8938657 - Effects of the 5-ht2 receptor antagonist ritanserin on halothane-induced increase of in...
24451597 - Muscle activation levels of the gluteus maximus and medius during standing hip-joint-st...
3434997 - The effect of thoracic epidural analgesia on postoperative stress and morbidity.
16388917 - Long-term effects of suppressing the preratio pause.
1938717 - Short-term effect of tidal pleural pressure swings on pulmonary blood flow during rest ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  56     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-06-06     Completed Date:  1984-06-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  415-20     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Animals
Cell Survival / drug effects
Cells, Cultured
Enflurane / pharmacology*
Guinea Pigs
Halothane / pharmacology*
Macrophages / drug effects*,  metabolism
Nitrous Oxide / pharmacology
Pulmonary Alveoli / cytology*
Time Factors
Chemical
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 13838-16-9/Enflurane; 151-67-7/Halothane; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of halothane on lymph flow.
Next Document:  Comparison of the effects of prizidilol and propranolol on renal haemodynamics at rest and during ex...