Document Detail

In vitro toxicity of halogenated anaesthetics on guineapig alveolar macrophages, surviving in gas phase.
MedLine Citation:
PMID:  6712857     Owner:  NLM     Status:  MEDLINE    
The potential toxicity of halogenated anaesthetics on cellular immunity has been investigated on guineapig macrophages in gas phase by measuring the adenosine 5' triphosphate (ATP) concentration in the macrophages. A toxicity index (TI) was obtained by comparing the ATP concentration in vapour or gas-exposed macrophages with that of control cells. The TI for 5% halothane in air after 24 h was 31.2 +/- 8.3%. The TI for 5% enflurane in air was 12.7 +/- 6.6% (P less than 0.01). In an oxygen-enriched gas mixture (60%), the halothane TI increased to 65 +/- 6.6%, whereas that for enflurane remained at 15.4 +/- 16.9% (P less than 0.01). In macrophages exposed to 1% halothane, or 2% enflurane, in 50% nitrous oxide in oxygen, for 3 and 6 h, the halothane TI (0.4 +/- 3.3%) and the enflurane TI (2.5 +/- 4.1%) did not differ significant from the control group after 3 h. However, after 6 h exposure the halothane TI (31.3 +/- 9.6%) and the enflurane TI (17 +/- 20%) were different (P = 0.05) from control. It is concluded that the prolonged administration of high concentrations of halothane and enflurane alone decreased macrophages ATP concentration. A high concentration of oxygen in the gas mixture increased significantly the halothane TI.
C Voisin; P A Scherpereel; C Aerts; D Lepot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  56     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-06-06     Completed Date:  1984-06-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  415-20     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphate / metabolism
Cell Survival / drug effects
Cells, Cultured
Enflurane / pharmacology*
Guinea Pigs
Halothane / pharmacology*
Macrophages / drug effects*,  metabolism
Nitrous Oxide / pharmacology
Pulmonary Alveoli / cytology*
Time Factors
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 13838-16-9/Enflurane; 151-67-7/Halothane; 56-65-5/Adenosine Triphosphate

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