| In vitro toxicity of halogenated anaesthetics on guineapig alveolar macrophages, surviving in gas phase. | |
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MedLine Citation:
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PMID: 6712857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The potential toxicity of halogenated anaesthetics on cellular immunity has been investigated on guineapig macrophages in gas phase by measuring the adenosine 5' triphosphate (ATP) concentration in the macrophages. A toxicity index (TI) was obtained by comparing the ATP concentration in vapour or gas-exposed macrophages with that of control cells. The TI for 5% halothane in air after 24 h was 31.2 +/- 8.3%. The TI for 5% enflurane in air was 12.7 +/- 6.6% (P less than 0.01). In an oxygen-enriched gas mixture (60%), the halothane TI increased to 65 +/- 6.6%, whereas that for enflurane remained at 15.4 +/- 16.9% (P less than 0.01). In macrophages exposed to 1% halothane, or 2% enflurane, in 50% nitrous oxide in oxygen, for 3 and 6 h, the halothane TI (0.4 +/- 3.3%) and the enflurane TI (2.5 +/- 4.1%) did not differ significant from the control group after 3 h. However, after 6 h exposure the halothane TI (31.3 +/- 9.6%) and the enflurane TI (17 +/- 20%) were different (P = 0.05) from control. It is concluded that the prolonged administration of high concentrations of halothane and enflurane alone decreased macrophages ATP concentration. A high concentration of oxygen in the gas mixture increased significantly the halothane TI. |
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Authors:
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C Voisin; P A Scherpereel; C Aerts; D Lepot |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 56 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-06-06 Completed Date: 1984-06-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 415-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Cell Survival / drug effects Cells, Cultured Enflurane / pharmacology* Guinea Pigs Halothane / pharmacology* Macrophages / drug effects*, metabolism Nitrous Oxide / pharmacology Pulmonary Alveoli / cytology* Time Factors |
| Chemical | |
Reg. No./Substance:
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10024-97-2/Nitrous Oxide; 13838-16-9/Enflurane; 151-67-7/Halothane; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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