Document Detail

In-vitro testing of three totally supra-annular bileaflet mechanical valves: hydrodynamics in the Sheffield pulse duplicator.
MedLine Citation:
PMID:  18512495     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM OF THE STUDY: In-vivo echocardiographic studies are limited by several confounding factors and technical pitfalls, and consequently the hypothetical differential hydraulic behavior between different prosthetic heart valves has not been identified. However, for surgeons it is essential to know the functional and geometric characteristics of the prostheses to be used. Herein, the in-vitro performance of two new supra-annular bileaflet prostheses--the Medtronic Advantage Supra and Sorin Bicarbon Overline--was compared with that of the 21-mm St. Jude Medical (SJM) Regent valve. METHODS: Three high-performance, production-quality prostheses, including the sewing-ring cuffs, were tested in the aortic chamber of a Sheffield pulse duplicator. The sizes of the prostheses which fitted the 21-mm valve holder were: 21 mm Advantage Supra Medtronic; 19 mm SJM Regent, and 18 mm Sorin Bicarbon Overline. The tests were carried out at a fixed pulse rate (70 beats/min), and at increasing cardiac output (CO) of 2, 4, 5, and 7 l/min. Forward-flow pressure drop, total regurgitant volume, closing and leakage volumes, effective orifice area (EOA) and stroke work loss (SWL) were recorded while the valve was operated at each CO. RESULTS: The SJM Regent and Sorin Bicarbon Overline valves each showed, at increasing CO, significantly lower mean and peak gradients. The calculated EOA and SWL were significantly better with the SJM Regent and Sorin Bicarbon Overline prostheses. The Medtronic Advantage Supra valve showed comparable results only while performing at 2 l/min CO. With regards to the regurgitant fraction, lowest values were observed with the Medtronic Advantage Supra valve. CONCLUSION: This hydrodynamic evaluation model allowed a comparison to be made of the efficiency of recently commercialized bileaflet prostheses, among which the older SJM Regent and the newer Sorin Bicarbon Overline valves demonstrated the best performances.
Tomaso Bottio; Vincenzo Tarzia; Giulio Rizzoli; Gino Gerosa
Related Documents :
12730815 - The relevance of large strains in functional tissue engineering of heart valves.
8257945 - Characteristics of arterial hypertension in response to bolus injection of phenylephrin...
23731705 - Parallel improvement of left ventricular geometry and filling pressure after transcathe...
15335425 - Decreases in ventricular volume correlate with decreases in ventricular pressure in idi...
20187715 - Comparative effects of carvedilol and lercanidipine on ultrafiltration and solute trans...
10854085 - Clinical pharmacokinetics of angiotensin ii (at1) receptor blockers in hypertension.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  17     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  222-6     Citation Subset:  IM    
Department of Cardiovascular Surgery, University of Padua Medical School, Padua, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Heart Valve Prosthesis*
Materials Testing
Pulsatile Flow

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Aortic valve replacement with 19-mm bileaflet prostheses in the elderly: left ventricular mass regre...
Next Document:  Are initial valve operations in octogenarians still high-risk in the current era?