Document Detail


In vitro testing of surface thrombogenicity using the thrombelastograph.
MedLine Citation:
PMID:  935639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Synthetic surfaces can be assessed for their ability to promote or inhibit whole blood coagulation with improved accuracy using a new protocol developed for the Thrombelastograph instrument. Results obtained from the analysis of the hydrodynamic state of blood clotting in Thrombelastograph chambers have enabled a quantitative interpretation of the output of this instrument to be made. The thrombogenic properties of a segmented polyurethane and a polydimethyl siloxane are compared with a preparation of reconstituted elastin. It is seen that a four-fold delay in clotting time is exhibited by reconstituted elastin when it is compared with other biomedical synthetic materials tested.
Authors:
S H Carr; L Zuckerman; J A Caprini; J P Vagher
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  13     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-19     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Coagulation*
Blood Coagulation Factors / analysis
Dimethylpolysiloxanes
Elastin
Humans
Statistics as Topic
Surface Properties
Thrombelastography* / instrumentation
Chemical
Reg. No./Substance:
0/Blood Coagulation Factors; 0/Dimethylpolysiloxanes; 9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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