Document Detail

In vitro testing of a left ventricular assist device. Study of the effect of its control strategy on energetic relationships inside the left ventricle.
MedLine Citation:
PMID:  8705398     Owner:  NLM     Status:  MEDLINE    
In this study an original left ventricular assist device is tested on an open loop modular physical circuit reproducing Starling's law of the heart to set an optimal control strategy for heart recovery. It is assumed that the goals of the assistance are reduction of oxygen consumption, external work and improvement of cardiac mechanical efficiency. The assistance is evaluated by the position of a working point on the characteristic surfaces of the ventricle defined by peripheral resistance, atrial pressure and selected variables pertaining to energy (pressure-volume area, external work and cardiac mechanical efficiency). In this frame an optimal assistance for heart recovery is a compromise among different requirements corresponding to a restricted set of control parameters values: driving pressure PZB = 35 kPa and timing values T1 and T2 (systole beginning and systole ending in relation to QRS complex and cardiac cycle duration T) T1 = 0.55.T and T2 = 0.73.T.
G Ferrari; K Gorczynska; C De Lazzari; K Grodzicki; R Mimmo; D Ambrosi; G Tosti
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Technology and health care : official journal of the European Society for Engineering and Medicine     Volume:  3     ISSN:  0928-7329     ISO Abbreviation:  Technol Health Care     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-10     Completed Date:  1996-09-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9314590     Medline TA:  Technol Health Care     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  231-9     Citation Subset:  IM    
Institute for Biomedical Technologies CNR, Rome, Italy.
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MeSH Terms
Bioelectric Energy Sources*
Biomedical Engineering
Computer Simulation
Electronics, Medical
Equipment Design
Heart-Assist Devices*
Models, Biological
Partial Pressure
Ventricular Function, Left*

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