Document Detail


In vitro susceptibility of Mycobacterium marinum to dihydromycoplanecin A and ten other antimicrobial agents.
MedLine Citation:
PMID:  2384640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro susceptibilities of 16 Mycobacterium marinum strains to 11 antimicrobial agents were determined by the Dubos Tween albumin liquid dilution technique. The results (MICs) were: 0.19-0.39 microgram/ml for dihydromycoplanecin A; 0.78-1.56 micrograms/ml for amikacin; 1.56-3.13 micrograms/ml for ofloxacin, norfloxacin and enoxacin; 1.56-6.25 micrograms/ml for minocycline; 1.56-25 micrograms/ml for sulfamethoxazole and sulfamethoxazole-trimethoprim; 3.13-12.5 micrograms/ml for oxytetracycline; 25-200 micrograms/ml for trimethoprim; and 50-200 micrograms/ml for pipemidic acid. The most active drugs were dihydromycoplanecine A and amikacin. Also active were minocycline, oxytetracycline, sulfamethoxazole and sulfamethoxazole-trimethoprim. Ofloxacin, norfloxacin and enoxacin demonstrated activity only at concentrations at or greater than those usually attained in serum. Pipemidic acid and trimethoprim were inactive.
Authors:
H Arai; H Nakajima; Y Kaminaga
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  17     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-18     Completed Date:  1990-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  370-4     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents* / pharmacology*
Humans
Japan
Microbial Sensitivity Tests
Mycobacteria, Atypical / drug effects*
Mycobacterium / drug effects*
Mycobacterium Infections, Atypical / drug therapy
Peptides*
Peptides, Cyclic / pharmacology
Skin Diseases, Infectious / drug therapy
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Peptides; 0/Peptides, Cyclic; 79003-68-2/dihydromycoplanecin A

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