| In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis. | |
| | |
MedLine Citation:
|
PMID: 12672149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Methanol extracts of the rhizomes of Sanguinaria canadensis, and the roots and rhizomes of Hydrastis canadensis, two plants used traditionally for the treatment of gastrointestinal ailments, were screened for in vitro antibacterial activity against 15 strains of Helicobacter pylori. The rhizome extracts, as well as a methanol extract of S. canadensis suspension-cell cultures inhibited the growth of H. pylori in vitro, with a MIC50 range of 12.5-50.0 microg/ml. Three isoquinoline alkaloids were identified in the active fraction. Sanguinarine and chelerythrine, two benzophenanthridine alkaloids, inhibited the growth of the bacterium, with an MIC50 of 50.0 and 100.0 microg/ml, respectively. Protopine, a protopine alkaloid, also inhibited the growth of the bacterium, with a MIC50 of 100 microg/ml. The crude methanol extract of H. canadensis rhizomes was very active, with an MIC50 of 12.5 microg/ml. Two isoquinoline alkaloids, berberine and beta-hydrastine, were identified as the active constituents, and having an MIC50 of 12.5 and 100.0 microg/ml, respectively. |
| | |
Authors:
|
Gail B Mahady; Susan L Pendland; Adenia Stoia; Lucas R Chadwick |
Related Documents
:
|
15884849 - Antioxidative activity of volatile extracts isolated from angelica tenuissimae roots, p... 16782649 - Usefulness of the sos chromotest in the study of medicinal plants as radioprotectors. 19873229 - A new method for the study of diffusion of biologically active material. 18066599 - Trypanocidal activity of extracts and compounds from the stem bark of anogeissus leioca... 519859 - Sensitive in vivo assay of the phenylalanine hydroxylating system with a small intraven... 17849289 - Sanionins: anti-inflammatory and antibacterial agents with weak cytotoxicity from the a... 16659949 - Rapid separation and quantification of abscisic acid from plant tissues using high perf... 8143029 - Chromium determination by supercritical fluid chromatography with inductively coupled p... 19382569 - Colorimetric determination of sildenafil citrate (viagra) through ion-associate complex... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Phytotherapy research : PTR Volume: 17 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2003 Mar |
Date Detail:
|
Created Date: 2003-04-02 Completed Date: 2003-05-27 Revised Date: 2009-06-09 |
Medline Journal Info:
|
Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
|
Languages: eng Pagination: 217-21 Citation Subset: IM |
Copyright Information:
|
Copyright 2003 John Wiley & Sons, Ltd. |
Affiliation:
|
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA. mahady@uic.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkaloids
/
administration & dosage,
pharmacology,
therapeutic use Anti-Bacterial Agents / administration & dosage, pharmacology*, therapeutic use Dose-Response Relationship, Drug Helicobacter Infections / drug therapy Helicobacter pylori / drug effects* Humans Hydrastis* Isoquinolines / administration & dosage, pharmacology, therapeutic use Microbial Sensitivity Tests Phytotherapy* Plant Extracts / administration & dosage, pharmacology*, therapeutic use Plant Roots Sanguinaria* |
| Grant Support | |
ID/Acronym/Agency:
|
AT00413/AT/NCCAM NIH HHS; R21 AT000412-01/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Alkaloids; 0/Anti-Bacterial Agents; 0/Isoquinolines; 0/Plant Extracts; 119-65-3/isoquinoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separat...
Next Document: Protection of jejunal crypts by RH-3 (a preparation of Hippophae rhamnoides) against lethal whole bo...