| In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin-spectinomycin. | |
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MedLine Citation:
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PMID: 12801456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The minimum inhibitory concentrations (MICs) of tetracycline, enrofloxacin, tylosin, spiramycin and a lincomycin:spectinomycin 1:2 combination, against 24 Sicilian isolates of Mycoplasma agalactiae, the causative organism of contagious agalactia were determined in vitro by a broth dilution method. Enrofloxacin was the most effective antimicrobial in vitro with a range of MIC values from 0.125 to 0.500 microg/ml and an MIC(50) of 0.203 and MIC(90) of 0.365 microg/ml. Using the MIC(50) and MIC(90) values the remaining four antimicrobials are ranked in order of in vitro effectiveness as follows: tylosin (MIC(50)0.292; MIC(90)0.525 microg/ml) was slightly more effective than tetracycline (MIC(50)0.296; MIC(90)0.533 microg/ml), followed by lincomycin:spectinomycin (MIC(50)0.521; MIC(90)0.938 microg/ml) and spiramycin (MIC(50)1.583; MIC(90)2.850 microg/ml). MIC values above 1.000 microg/ml were obtained using tetracycline, tylosin and spiramycin for some M. agalactiae isolates. |
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Authors:
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G R Loria; C Sammartino; R A J Nicholas; R D Ayling |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research in veterinary science Volume: 75 ISSN: 0034-5288 ISO Abbreviation: Res. Vet. Sci. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-06-12 Completed Date: 2003-08-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: England |
Other Details:
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Languages: eng Pagination: 3-7 Citation Subset: IM |
Affiliation:
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Institute Zooprofilattico, Sperimentale della Sicilia, Via Rocco Dicillo, 4 I-90129, Palermo, Sicily, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / pharmacology* Anti-Infective Agents / pharmacology Female Fluoroquinolones* Lincomycin / pharmacology Microbial Sensitivity Tests Mycoplasma / drug effects*, isolation & purification Mycoplasma Infections / drug therapy, microbiology, veterinary* Oxytetracycline / pharmacology Quinolones / pharmacology Sheep Sheep Diseases / drug therapy, microbiology* Sicily Spectinomycin / pharmacology Spiramycin / pharmacology Tylosin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Fluoroquinolones; 0/Quinolones; 1401-69-0/Tylosin; 154-21-2/Lincomycin; 1695-77-8/Spectinomycin; 79-57-2/Oxytetracycline; 8025-81-8/Spiramycin; 93106-60-6/enrofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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