Document Detail


In vitro studies: what is their role in toxicology?
MedLine Citation:
PMID:  16092726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many epidemiology studies have reported associations between inhaled environmental pollutants, especially particles, and mortality or morbidity. Despite these impressive associations, fundamental uncertainties exist as to the underlying pathophysiological mechanisms responsible for mortality or morbidity following exposure to air pollutants. In vitro toxicology provides a powerful approach to describe these mechanisms at the cellular, biochemical, and molecular level. This manuscript will describe some advantages and limitations of in vitro toxicology studies in comparison with epidemiology studies, and human and animal exposure studies. A recent example will also be presented which demonstrates that the response of cultured cells to air pollution particles is similar to the response seen following in vivo exposure to the same particles. This coherence between an in vivo and in vitro response provides relevance to additional in vitro studies that characterize the mechanisms by which these particles cause adverse health effects.
Authors:
Robert B Devlin; Mark L Frampton; Andrew J Ghio
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie     Volume:  57 Suppl 1     ISSN:  0940-2993     ISO Abbreviation:  Exp. Toxicol. Pathol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-08-11     Completed Date:  2005-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9208920     Medline TA:  Exp Toxicol Pathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
Affiliation:
National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. devlin.robert@epa.gov
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants / adverse effects*
Animals
Bronchi / drug effects*,  metabolism,  pathology
Bronchoalveolar Lavage Fluid / chemistry
Cell Line
Dose-Response Relationship, Drug
Humans
Inhalation Exposure / adverse effects*
Interleukin-8 / metabolism
Lung Diseases / chemically induced*,  epidemiology,  pathology
Respiratory Mucosa / drug effects*,  metabolism,  pathology
Toxicity Tests / methods*
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Interleukin-8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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