| In vitro studies: what is their role in toxicology? | |
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MedLine Citation:
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PMID: 16092726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many epidemiology studies have reported associations between inhaled environmental pollutants, especially particles, and mortality or morbidity. Despite these impressive associations, fundamental uncertainties exist as to the underlying pathophysiological mechanisms responsible for mortality or morbidity following exposure to air pollutants. In vitro toxicology provides a powerful approach to describe these mechanisms at the cellular, biochemical, and molecular level. This manuscript will describe some advantages and limitations of in vitro toxicology studies in comparison with epidemiology studies, and human and animal exposure studies. A recent example will also be presented which demonstrates that the response of cultured cells to air pollution particles is similar to the response seen following in vivo exposure to the same particles. This coherence between an in vivo and in vitro response provides relevance to additional in vitro studies that characterize the mechanisms by which these particles cause adverse health effects. |
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Authors:
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Robert B Devlin; Mark L Frampton; Andrew J Ghio |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Volume: 57 Suppl 1 ISSN: 0940-2993 ISO Abbreviation: Exp. Toxicol. Pathol. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-08-11 Completed Date: 2005-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9208920 Medline TA: Exp Toxicol Pathol Country: Germany |
Other Details:
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Languages: eng Pagination: 183-8 Citation Subset: IM |
Affiliation:
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National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. devlin.robert@epa.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants
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adverse effects* Animals Bronchi / drug effects*, metabolism, pathology Bronchoalveolar Lavage Fluid / chemistry Cell Line Dose-Response Relationship, Drug Humans Inhalation Exposure / adverse effects* Interleukin-8 / metabolism Lung Diseases / chemically induced*, epidemiology, pathology Respiratory Mucosa / drug effects*, metabolism, pathology Toxicity Tests / methods* |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/Interleukin-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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