| In vitro studies on the relationship between the anti-inflammatory activity of Physalis peruviana extracts and the phagocytic process. | |
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MedLine Citation:
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PMID: 19678736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study of plants used in traditional medicine has drawn the attention of researchers as an alternative in the development of new therapeutics agents, such as the American Solanaceae Physalis peruviana, which has significant anti-inflammatory activity. The Physalis peruviana anti-inflammatory effect of ethanol or ether calyces extracts on the phagocytic process was assessed by using an in vitro phagocytosis model (Leishmania panamensis infection to murine macrophages). The Physalis peruviana extracts do not inhibit microorganism internalization and have no parasiticide effect. Most ET and EP extracts negatively affected the parasite's invasion of macrophages (Infected cells increased.). This observation might result from a down-regulation of the macrophage's microbicide ability associated with a selective reduction of proinflammatory cytokines levels. Physalis peruviana's anti-inflammatory activity described in this model is related to an immunomodulatory effect exerted on macrophages infected, which directly or indirectly "blocks" their ability to secrete soluble proinflammatory mediators. |
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Authors:
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Willington Mart?nez; Luis Fernando Ospina; Diana Granados; Gabriela Delgado |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunopharmacology and immunotoxicology Volume: 32 ISSN: 1532-2513 ISO Abbreviation: Immunopharmacol Immunotoxicol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800150 Medline TA: Immunopharmacol Immunotoxicol Country: England |
Other Details:
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Languages: eng Pagination: 63-73 Citation Subset: IM |
Affiliation:
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Immunotoxicology Research Group, Science Faculty, National University of Colombia, Bogot?, Colombia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / pharmacology* Cell Line Leishmania / immunology Macrophages / immunology, parasitology Mice Phagocytosis / drug effects* Physalis* Plant Extracts / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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