Document Detail


In vitro studies on the relationship between the anti-inflammatory activity of Physalis peruviana extracts and the phagocytic process.
MedLine Citation:
PMID:  19678736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study of plants used in traditional medicine has drawn the attention of researchers as an alternative in the development of new therapeutics agents, such as the American Solanaceae Physalis peruviana, which has significant anti-inflammatory activity. The Physalis peruviana anti-inflammatory effect of ethanol or ether calyces extracts on the phagocytic process was assessed by using an in vitro phagocytosis model (Leishmania panamensis infection to murine macrophages). The Physalis peruviana extracts do not inhibit microorganism internalization and have no parasiticide effect. Most ET and EP extracts negatively affected the parasite's invasion of macrophages (Infected cells increased.). This observation might result from a down-regulation of the macrophage's microbicide ability associated with a selective reduction of proinflammatory cytokines levels. Physalis peruviana's anti-inflammatory activity described in this model is related to an immunomodulatory effect exerted on macrophages infected, which directly or indirectly "blocks" their ability to secrete soluble proinflammatory mediators.
Authors:
Willington Mart?nez; Luis Fernando Ospina; Diana Granados; Gabriela Delgado
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunopharmacology and immunotoxicology     Volume:  32     ISSN:  1532-2513     ISO Abbreviation:  Immunopharmacol Immunotoxicol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800150     Medline TA:  Immunopharmacol Immunotoxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-73     Citation Subset:  IM    
Affiliation:
Immunotoxicology Research Group, Science Faculty, National University of Colombia, Bogot?, Colombia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology*
Cell Line
Leishmania / immunology
Macrophages / immunology,  parasitology
Mice
Phagocytosis / drug effects*
Physalis*
Plant Extracts / pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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