Document Detail

In vitro studies of nuclear volume of rat adrenocortical cells: lace of ACTH effect.
MedLine Citation:
PMID:  6161494     Owner:  NLM     Status:  MEDLINE    
The effect of ACTH on nuclear volume of adrenocortical cells in the zona fasciculata of rat adrenal cortex was examined in vitro. Sections of adrenal gland were incubated for 60 or 90 min in Krebs-Ringer's solution with 1% glucose in the presence of ACTH, actinomycin D, cycloheximide and aminoglutethimide. ACTH, despite its clear effect in stimulating steroidogenesis, did not exert a direct effect on the nuclear volume of cells studied. This phenomenon is not dependent upon the stimulation of steroidogenesis, since aminoglutethimide does not influence the nuclear volume of adrenocortical cells studied; rather, ACTH in the presence of aminoglutethimide leads to a decrease in their volume. Actinomycin D does not influence nuclear volume while after incubation with cycloheximide nuclei were larger than the control. The presence of ACTH did not alter this effect. These results indicate no relationship between the degree of corticosterone output and nuclear volume in rat adrenocortical cells of the zona fasciculata in vitro.
L K Malendowicz; P Fichna; L Sulanowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für mikroskopisch-anatomische Forschung     Volume:  94     ISSN:  0044-3107     ISO Abbreviation:  Z Mikrosk Anat Forsch     Publication Date:  1980  
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413637     Medline TA:  Z Mikrosk Anat Forsch     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  721-32     Citation Subset:  IM    
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MeSH Terms
Adrenal Cortex / drug effects,  ultrastructure*
Adrenocorticotropic Hormone / pharmacology*
Aminoglutethimide / pharmacology
Cell Nucleus / drug effects
Corticosterone / biosynthesis
Cycloheximide / pharmacology
Dactinomycin / pharmacology
Reg. No./Substance:
125-84-8/Aminoglutethimide; 50-22-6/Corticosterone; 50-76-0/Dactinomycin; 66-81-9/Cycloheximide; 9002-60-2/Adrenocorticotropic Hormone

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