Document Detail

In-vitro studies on mechanisms of immunosuppression associated with bovine respiratory syncytial virus.
MedLine Citation:
PMID:  9651810     Owner:  NLM     Status:  MEDLINE    
Bovine respiratory syncytial virus (BRSV) depressed the proliferative reactivity of normal ovine peripheral blood lymphocytes to phytohaemagglutinin (PHA). This BRSV-induced reduction in proliferative reactivity was not reversed or ameliorated by the addition of (1) indomethacin or flunixin meglumine, substances known to inhibit the production of prostaglandins, or (2) the cytokines, interleukin-1 (IL-1) and interleukin-2 (IL-2), or (3) rat growth factor. The results suggest that the suppression of ovine lymphocyte reactivity to PHA associated with BRSV was not caused by the release of cyclooxygenase products such as prostaglandins, or the production of inhibitors of IL-1 or IL-2.
I Keles; Z Woldehiwet; R D Murray
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of comparative pathology     Volume:  118     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-15     Completed Date:  1998-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  337-45     Citation Subset:  IM    
University of Liverpool, Department of Veterinary Clinical Science and Animal Husbandry, Neston, South Wirral, UK.
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MeSH Terms
Cell Division / drug effects
Clonixin / analogs & derivatives,  pharmacology
Cyclooxygenase Inhibitors / pharmacology
Cytokines / pharmacology
Dinoprostone / metabolism
Escherichia coli
Immune Tolerance*
Indomethacin / pharmacology
Lipopolysaccharides / pharmacology
Lymphocyte Activation* / drug effects
Phytohemagglutinins / pharmacology
Prostaglandin Antagonists / pharmacology
Recombinant Proteins
Respiratory Syncytial Virus Infections / immunology,  veterinary*
Respiratory Syncytial Virus, Bovine / immunology*
Sheep Diseases / immunology*,  virology
T-Lymphocytes / drug effects,  immunology*
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Cytokines; 0/Lipopolysaccharides; 0/Phytohemagglutinins; 0/Prostaglandin Antagonists; 0/Recombinant Proteins; 17737-65-4/Clonixin; 363-24-6/Dinoprostone; 42461-84-7/flunixin meglumine; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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