Document Detail

In vitro studies of early cardiac remodeling: impact on contraction and calcium handling.
MedLine Citation:
PMID:  21622254     Owner:  NLM     Status:  MEDLINE    
Cardiac remodeling, hypertrophy, and alterations in calcium signaling are changes of the heart that often lead to failure. After a hypertrophic stimulus, the heart progresses through a state of compensated hypertrophy which over time leads to decompensated hypertrophy or failure. It is at this point that a cardiac transplant is required for survival making early detection imperative. Current experimental systems used to study the remodeling of the heart include in vivo systems (the whole body), isolated organ and sub-organ tissue, and the individual cardiac muscle cells and organelles.. During pathological remodeling there is a derangement in the intracellular calcium handling processes. These derangements are thought to lead to a dysregulation of contractile output. Hence, understanding the mechanism between remodeling and dysregulation is of great interest in the cardiac field and will ultimately help in the development of future treatment and early detection. This review will center on changes in contraction and calcium handling in early cardiac remodeling, with a specific focus on findings in two different in vitro model systems: multicellular and individual cell preparations.
Kaylan M Haizlip; Paul M L Janssen
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-06-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  3     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-30     Completed Date:  2011-09-26     Revised Date:  2013-07-21    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1047-57     Citation Subset:  IM    
Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH 43210-1218, USA.
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MeSH Terms
Actin Cytoskeleton / metabolism*,  physiology
Calcium / metabolism*
Calcium Signaling / physiology*
Cells, Cultured
Models, Biological*
Myocardial Contraction / physiology*
Myocytes, Cardiac / physiology*
Ventricular Remodeling / physiology*
Grant Support
Reg. No./Substance:

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