Document Detail

In vitro studies on the cellular immune response of tumor-bearing mice to SV40-transformed cells.
MedLine Citation:
PMID:  163278     Owner:  NLM     Status:  MEDLINE    
Specific cell-mediated immunity to SV 40 tumor-specific transplantation antigen (TSTA) in mice undergoing tumorigenesis by syngeneic SV 40-transformed BALB/C cells was investigated by the macrophage migration inhibition (MMI) and transplantation rejection tests. Specific cellular reactivity to SV40 TSTA could be demonstrated in BALB/c mice early after tumor cell inoculation. This activity was no longer detectable during the later stages of tumor growth but was again demonstrable 2 weeks after tumor excision. Addition of an equal number of non-reactive peritoneal exudate (PE) cells from tumor-bearing mice to PE cells from mice immune to SV40 TSTA specifically abrogated the reactivity of the latter cells to soluble SV40 TSTA. When lymphoid cells with blocking activity were cultured in vitro they not only lost their blocking capacity but also regained their reactivity to SV40 TSTA in the MMI test. These findings indicate that tumor-bearing hosts possess lymphocytes specifically sensitized to the TSTA of the tumor and that the specific reactivity of these cells can be regained after culture in vitro.
J W Blasecki; S S Tevethia
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  114     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-05-21     Completed Date:  1975-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  244-9     Citation Subset:  AIM; IM    
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MeSH Terms
Antigens, Neoplasm*
Antigens, Viral
Cell Line
Cell Migration Inhibition
Cell Transformation, Neoplastic
Cells, Cultured
Graft Rejection
Histocompatibility Antigens
Immunity, Cellular*
Lymphocytes / immunology*
Macrophages / immunology
Mice, Inbred BALB C
Neoplasm Transplantation
Neoplasms, Experimental / surgery
Simian virus 40 / immunology*
Transplantation, Homologous
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Antigens, Viral; 0/Histocompatibility Antigens; 56-49-5/Methylcholanthrene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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