| In-vitro studies of aging. | |
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MedLine Citation:
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PMID: 2424654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Research has conclusively established that normal diploid cells in culture have a limited replicative life span, and that cells from adult organisms have a shorter life span than cells from young organisms or embryos. Although it is unlikely that death of the organism is caused by failure in cellular proliferative capacity, the changes that accompany alterations in proliferative capacity may play significant roles in organismic aging. The causes of the decreased proliferative vigor of cells with age are not known, but one factor may reside in the fact that with increasing in-vitro or donor age, cells become less able to respond to mitogens. Additionally, it is known that proliferative capacity of cells in culture is under genetic control, although this control can be modified by environmental factors. Thus, although the precise relationship between in-vitro and in-vivo aging remains undefined, advances in technology give hope that a delineation of this relationship may in time be achieved and, with it, an increased understanding of organismic senescence. |
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Authors:
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B Praeger |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Dermatologic clinics Volume: 4 ISSN: 0733-8635 ISO Abbreviation: Dermatol Clin Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-08-19 Completed Date: 1986-08-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8300886 Medline TA: Dermatol Clin Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 359-69 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Cattle Cell Differentiation / drug effects Cell Division / drug effects Cell Line Cell Survival* / drug effects Cells, Cultured Chick Embryo Cytogenetics DNA / biosynthesis DNA Repair Diploidy Embryo, Mammalian Fetus Fibroblasts / physiology Growth Substances / pharmacology Guinea Pigs Humans Mice RNA / biosynthesis Rats Skin / cytology |
| Chemical | |
Reg. No./Substance:
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0/Growth Substances; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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