Document Detail

In vitro stimulation of penetration gland emptying by Trichobilharzia szidati and T. regenti (Schistosomatidae) cercariae. Quantitative collection and partial characterization of the products.
MedLine Citation:
PMID:  15868186     Owner:  NLM     Status:  MEDLINE    
Induction of penetration gland emptying by cercariae of the bird schistosomes Trichobilharzia szidati and T. regenti employing linoleic acid, linolenic acid, praziquantel and calcium ionophore A23187 showed that both postacetabular and circumacetabular cells released their content at chosen stimulant concentrations. The gland secretions consisted of soluble and insoluble parts. The former one adhering to the ground seemed to have different saccharide composition from the glands of Schistosoma mansoni. It bound labelled saccharides, thus exhibiting lectin-like activity. Protein profiles of the latter one were identical after stimulation by all four stimulants in T. szidati. The soluble secretions contained several proteolytic enzymes; 31 kDa and 33 kDa cysteine proteases were identified in E/S products of T. szidati and T. regenti, respectively. The circumacetabular glands contained a significant amount of calcium. Immunohistochemistry revealed that the origin of E/S products after in vitro stimulation is in both penetration glands and tegumental structures. No crossreactivity was observed between the bird schistosomes and a serum raised against S. mansoni elastase.
Libor Mikes; Lenka Zìdková; Martin Kasný; Jan Dvorák; Petr Horák
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-05-03
Journal Detail:
Title:  Parasitology research     Volume:  96     ISSN:  0932-0113     ISO Abbreviation:  Parasitol. Res.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-01     Completed Date:  2005-10-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8703571     Medline TA:  Parasitol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  230-41     Citation Subset:  IM    
Department of Parasitology, Charles University, Vinicná 7, 12844, Prague 2, Czech Republic,
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MeSH Terms
Anthelmintics / pharmacology
Calcimycin / pharmacology
Dose-Response Relationship, Drug
Exocrine Glands / drug effects,  secretion*
Helminth Proteins / chemistry,  metabolism*
Host-Parasite Interactions / physiology
Linoleic Acids / pharmacology
Linolenic Acids / pharmacology
Mice, Inbred BALB C
Praziquantel / pharmacology
Schistosomatidae / drug effects,  metabolism*
Reg. No./Substance:
0/Anthelmintics; 0/Helminth Proteins; 0/Linoleic Acids; 0/Linolenic Acids; 52665-69-7/Calcimycin; 55268-74-1/Praziquantel

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