| In vitro stability predictions for the bone/hydroxyapatite composite system. | |
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MedLine Citation:
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PMID: 9788504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electroacoustic measurements of the zeta (zeta) potential as a function of pH were collected and used to probe the nature of the ionic contributions to the bond formed between synthetic hydroxyapatite (HA) and bone. HA powder and wet bone powder were dispersed into an electrolyte solution comprised of physiologic saline (0.154M NaCl), electroacoustic measurements collected, and the zeta potential calculated as a function of pH. The zeta potential and particle size then were used to calculate the stability of the composite dispersion, where stability is the ability of a particulate suspension to remain unagglomerated. The stability was used to predict the homo- (HA to HA and bone to bone) versus heterocoagulation (HA to bone) behaviors for the HA/bone system. Although single component bone and HA demonstrated stability against agglomeration, the HA/bone interaction was determined to be unstable for all pH levels tested, including pH 7.4, the normal in vivo pH. These results establish one factor responsible for the observed physicochemical bonding between bone and HA noted by many in the orthopedic community. |
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Authors:
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D A Oppermann; M J Crimp; D M Bement |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomedical materials research Volume: 42 ISSN: 0021-9304 ISO Abbreviation: J. Biomed. Mater. Res. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1998-12-23 Completed Date: 1998-12-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0112726 Medline TA: J Biomed Mater Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 412-6 Citation Subset: IM |
Affiliation:
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Department of Materials Science & Mechanics, Michigan State University, East Lansing 48824-1226, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone and Bones
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chemistry* Durapatite / chemistry* Hydrogen-Ion Concentration Static Electricity |
| Chemical | |
Reg. No./Substance:
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1306-06-5/Durapatite |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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