| In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions. | |
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MedLine Citation:
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PMID: 21709094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim of this study was to define the in vitro pH-activity relationship. Finafloxacin exhibited optimal antibacterial activity between pH 5.0 and 6.0 at which MICs were 4- to 8-fold lower than those determined at neutral pH. These observations were then confirmed against a larger collection of bacteria. These data suggest that finafloxacin could potentially offer a therapeutic advantage within acidic foci of infection. |
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Authors:
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Will Stubbings; Pamela Leow; Goh Chee Yong; Falicia Goh; Barbara Körber-Irrgang; Michael Kresken; Rainer Endermann; Harald Labischinski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-06-27 |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 55 ISSN: 1098-6596 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-18 Completed Date: 2012-01-09 Revised Date: 2012-03-01 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
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Languages: eng Pagination: 4394-7 Citation Subset: IM |
Affiliation:
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MerLion Pharmaceuticals GmbH, Robert-Rössle Strasse 10, Berlin, Germany. william.stubbings@basilea.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology* Ciprofloxacin / pharmacology Escherichia coli / drug effects Fluoroquinolones / pharmacology* Hydrogen-Ion Concentration Klebsiella pneumoniae / drug effects Microbial Sensitivity Tests Ofloxacin / pharmacology Pseudomonas aeruginosa / drug effects Staphylococcus aureus / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Fluoroquinolones; 0/finafloxacin; 82419-36-1/Ofloxacin; 85721-33-1/Ciprofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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