| In vitro and short-term in vivo characteristics of a Kel-F thin film modified glucose sensor. | |
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MedLine Citation:
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PMID: 14640443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new outer layer composition, consisting of polytetrafluoroethylene (PTFE), Kel-F oil, and Nafion, is suggested to minimize the detrimental effect of dissolved oxygen and to extend the linear response range of a glucose oxidase(GOx)-based sensor using nonconducting polymer. The morphology of Kel-F/PTFE/Kel-F/Nafion polymeric laminate was followed during fabrication by SEM. When Kel-F film was formed on the PTFE outer layer, the linear response was extended to 21 mM, at a sensitivity of 2.8 +/- 0.8 nA/mM mm2. We demonstrate that a sensor without Kel-F/PTFE/Kel-F/Nafion outer layer is relatively oxygen dependent, whereas by comparison a sensor with Kel-F/PTFE/Kel-F/Nafion outer layer is oxygen independent. The current of such a glucose sensor implanted in the subcutaneous tissue stabilized within 60 min, and the lag between blood glucose changes and sensor output was within 1 min. The in vivo characteristics of the glucose sensor described show great promise for one-point in vivo calibration. |
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Authors:
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Sun Kil Kang; Ran-A Jeong; Sejin Park; Taek Dong Chung; Sunmin Park; Hee Chan Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry Volume: 19 ISSN: 0910-6340 ISO Abbreviation: Anal Sci Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-26 Completed Date: 2004-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511078 Medline TA: Anal Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1481-6 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 110-744, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biosensing Techniques / methods* Blood Glucose / analysis* Electrodes Fluorocarbon Polymers / chemistry Glucose Oxidase / chemistry* Male Microscopy, Electron, Scanning Oxygen / chemistry Polytetrafluoroethylene / chemistry Rats Rats, Sprague-Dawley Reproducibility of Results Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fluorocarbon Polymers; 39464-59-0/perfluorosulfonic acid; 7782-44-7/Oxygen; 9002-84-0/Polytetrafluoroethylene; EC 1.1.3.4/Glucose Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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