Document Detail

In vitro and short-term in vivo characteristics of a Kel-F thin film modified glucose sensor.
MedLine Citation:
PMID:  14640443     Owner:  NLM     Status:  MEDLINE    
A new outer layer composition, consisting of polytetrafluoroethylene (PTFE), Kel-F oil, and Nafion, is suggested to minimize the detrimental effect of dissolved oxygen and to extend the linear response range of a glucose oxidase(GOx)-based sensor using nonconducting polymer. The morphology of Kel-F/PTFE/Kel-F/Nafion polymeric laminate was followed during fabrication by SEM. When Kel-F film was formed on the PTFE outer layer, the linear response was extended to 21 mM, at a sensitivity of 2.8 +/- 0.8 nA/mM mm2. We demonstrate that a sensor without Kel-F/PTFE/Kel-F/Nafion outer layer is relatively oxygen dependent, whereas by comparison a sensor with Kel-F/PTFE/Kel-F/Nafion outer layer is oxygen independent. The current of such a glucose sensor implanted in the subcutaneous tissue stabilized within 60 min, and the lag between blood glucose changes and sensor output was within 1 min. The in vivo characteristics of the glucose sensor described show great promise for one-point in vivo calibration.
Sun Kil Kang; Ran-A Jeong; Sejin Park; Taek Dong Chung; Sunmin Park; Hee Chan Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry     Volume:  19     ISSN:  0910-6340     ISO Abbreviation:  Anal Sci     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-26     Completed Date:  2004-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8511078     Medline TA:  Anal Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1481-6     Citation Subset:  IM    
Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 110-744, Korea.
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MeSH Terms
Biosensing Techniques / methods*
Blood Glucose / analysis*
Fluorocarbon Polymers / chemistry
Glucose Oxidase / chemistry*
Microscopy, Electron, Scanning
Oxygen / chemistry
Polytetrafluoroethylene / chemistry
Rats, Sprague-Dawley
Reproducibility of Results
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/Fluorocarbon Polymers; 39464-59-0/perfluorosulfonic acid; 7782-44-7/Oxygen; 9002-84-0/Polytetrafluoroethylene; EC Oxidase

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