| In vitro sensitivity of Plasmodium falciparum to drugs that bind DNA or inhibit its synthesis. | |
| | |
MedLine Citation:
|
PMID: 8410555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The in vitro sensitivity of Plasmodium falciparum to bleomycin, busulfan, camptothecin, CC-1065, cisplatin, daunomycin, distamycin, luzopeptin, mAMSA, mitomycin C, naladixic acid, U71184, VM26, and VP16, or combinations of them was examined. The lethal dose concentration for 50% of parasites for 3 compounds, luzopeptin, CC1065, and U71184, that bind to adenine-thymidine-rich nucleotide sequences, were in the range of 10(-11) M. They were at least 2 orders of magnitude more effective than the other compounds. |
| | |
Authors:
|
S Lee; J Inselburg |
Related Documents
:
|
851535 - Synthesis of polynucleotides which contain 3,n4-ethanocytidine, a nucleoside modificati... 17203505 - Capillary electrophoretic method for nucleotide analysis in cells: application on inher... 21710465 - In vitro genotoxicity assessment of caffeic, cinnamic and ferulic acids. 6095845 - The effect of oncomodulin on camp phosphodiesterase activity. 9444885 - Hyperoxia and glutathione depletion in the isolated perfused rat liver. 3837035 - Plasma free fatty acid levels during cold-induced and noradrenaline-induced nonshiverin... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of parasitology Volume: 79 ISSN: 0022-3395 ISO Abbreviation: J. Parasitol. Publication Date: 1993 Oct |
Date Detail:
|
Created Date: 1993-11-24 Completed Date: 1993-11-24 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7803124 Medline TA: J Parasitol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 780-2 Citation Subset: IM |
Affiliation:
|
Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibiotics, Antineoplastic / metabolism, pharmacology Antineoplastic Agents / metabolism, pharmacology Antiprotozoal Agents / metabolism, pharmacology* DNA, Protozoan / biosynthesis, metabolism* Indoles / metabolism, pharmacology Leucomycins / metabolism, pharmacology Plasmodium falciparum / drug effects*, genetics Quinolines / metabolism, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
|
AI 5ROI20437/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antibiotics, Antineoplastic; 0/Antineoplastic Agents; 0/Antiprotozoal Agents; 0/DNA, Protozoan; 0/Indoles; 0/Leucomycins; 0/Quinolines; 101222-80-4/U 71184; 134688-25-8/luzopeptin; 69866-21-3/CC 1065 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Third-stage larvae emerge from eggs of Contracaecum osculatum (Nematoda, Anisakidae).
Next Document: Infection of immunodeficient mice with a mouse-adapted substrain of the gray strain of Babesia micro...