| In vitro screening of tumoricidal properties of international medicinal herbs: part II. | |
| | |
MedLine Citation:
|
PMID: 20564497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
With growing use of anticancer complementary and alternative medicines (CAMs) worldwide, there is a need to assess and screen commercially available natural products for relative tumoricidal properties under standard experimental conditions. In the current study, we screened and ranked 264 traditional Chinese and Egyptian herbal medicines for tumoricidal potency against malignant neuroblastoma in vitro. The data obtained show that tumoricidal potencies of plants were randomly dispersed throughout similar orders, families and genera under the Division: Magnoliophyta, class: Magnoliopsida, subclasses: Asteridae, Caryophyllidae, Dilleniidae, Hamamelididae, Magnoliidae and Rosidae. The most potent plant extracts (LC₅₀ < 0.08 mg/ml) were prepared from gromwell root also known as 'Hong Tiao Zi Cao' (Lithospermum Erythrorhizon) Family (Boraginaceae) > beth root (Trillium Pendulum), Family (Liliaceae) and galbanum (Ferula Galbaniflua), Family (Apiaceae). Gromwell root is traditionally used in the preparation of Chinese medicinal tea. In addition, galbanum was highly regarded for its sacred and medicinal value according to ancient texts and the bible. Future research will be required to isolate and identify chemical constituents within these plants which are responsible for tumoricidal effects. |
| | |
Authors:
|
Elizabeth A Mazzio; Karam F A Soliman |
Related Documents
:
|
19857257 - Comparative analysis of medicinal plants used in traditional medicine in italy and tuni... 16508197 - New neolignans and lignans from vietnamese medicinal plant machilus odoratissima nees. 15974487 - A computer method for validating traditional chinese medicine herbal prescriptions. 6257917 - Psychoneuroendocrinology, biorhythms, and chinese medicine. 2479407 - Anaesthetic management of malignant tracheo-oesophageal fistula. 2740927 - Active patients: the integration of modern and traditional obstetric practices in nepal. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Phytotherapy research : PTR Volume: 24 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2011-02-17 Revised Date: 2011-03-03 |
Medline Journal Info:
|
Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
|
Languages: eng Pagination: 1813-24 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
|
College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antineoplastic Agents, Phytogenic / chemistry* Apiaceae / chemistry Boraginaceae / chemistry Cell Line, Tumor Drug Screening Assays, Antitumor Drugs, Chinese Herbal / chemistry Liliaceae / chemistry Mice Neuroblastoma / drug therapy Plant Extracts / chemistry* Plants, Medicinal / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
|
G12 RR003020-255367/RR/NCRR NIH HHS; G12RR03020/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents, Phytogenic; 0/Drugs, Chinese Herbal; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Zingiber officinale (ginger) compounds have tetracycline-resistance modifying effects against clinic...
Next Document: Antiinflammatory effects of Epimedium brevicornum water extract on lipopolysaccharide-activated RAW2...