Document Detail


In vitro screening of tumoricidal properties of international medicinal herbs: part II.
MedLine Citation:
PMID:  20564497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With growing use of anticancer complementary and alternative medicines (CAMs) worldwide, there is a need to assess and screen commercially available natural products for relative tumoricidal properties under standard experimental conditions. In the current study, we screened and ranked 264 traditional Chinese and Egyptian herbal medicines for tumoricidal potency against malignant neuroblastoma in vitro. The data obtained show that tumoricidal potencies of plants were randomly dispersed throughout similar orders, families and genera under the Division: Magnoliophyta, class: Magnoliopsida, subclasses: Asteridae, Caryophyllidae, Dilleniidae, Hamamelididae, Magnoliidae and Rosidae. The most potent plant extracts (LC₅₀ < 0.08 mg/ml) were prepared from gromwell root also known as 'Hong Tiao Zi Cao' (Lithospermum Erythrorhizon) Family (Boraginaceae) > beth root (Trillium Pendulum), Family (Liliaceae) and galbanum (Ferula Galbaniflua), Family (Apiaceae). Gromwell root is traditionally used in the preparation of Chinese medicinal tea. In addition, galbanum was highly regarded for its sacred and medicinal value according to ancient texts and the bible. Future research will be required to isolate and identify chemical constituents within these plants which are responsible for tumoricidal effects.
Authors:
Elizabeth A Mazzio; Karam F A Soliman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  24     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-02-17     Revised Date:  2013-07-19    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1813-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Affiliation:
College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / chemistry*
Apiaceae / chemistry
Boraginaceae / chemistry
Cell Line, Tumor
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal / chemistry
Liliaceae / chemistry
Mice
Neuroblastoma / drug therapy
Plant Extracts / chemistry*
Plants, Medicinal / chemistry*
Grant Support
ID/Acronym/Agency:
G12 RR003020/RR/NCRR NIH HHS; G12 RR003020-255367/RR/NCRR NIH HHS; G12RR03020/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Drugs, Chinese Herbal; 0/Plant Extracts
Comments/Corrections

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