Document Detail


In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188.
MedLine Citation:
PMID:  10898700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the new formulation was 100 times less than that of the control AmB formulation.
Authors:
S Espuelas; P Legrand; P M Loiseau; C Bories; G Barratt; J M Irache
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  44     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-10-05     Completed Date:  2000-10-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2190-2     Citation Subset:  IM    
Affiliation:
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Navarra, 31080 Pamplona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Amphotericin B / pharmacology*
Animals
Antiprotozoal Agents / pharmacology*
Betaine / analogs & derivatives*,  pharmacology
Drug Evaluation, Preclinical
Drug Resistance, Microbial
Drug Synergism
Inhibitory Concentration 50
Leishmania donovani / drug effects*
Microbial Sensitivity Tests
Poloxamer / pharmacology*
Chemical
Reg. No./Substance:
0/Antiprotozoal Agents; 106392-12-5/Poloxamer; 107-43-7/Betaine; 138673-85-5/desintegron B; 1397-89-3/Amphotericin B
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