Document Detail


In vitro prostaglandin E2 production by glioblastoma cells and its effect on interleukin-2 activation of oncolytic lymphocytes.
MedLine Citation:
PMID:  2175768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glioblastoma cells constitutively produce various amounts of PGE2 (prostaglandin E2) in vitro. The amounts of PGE2 found in the conditioned medium of the glioblastoma cultures (less than 5 ng/ml) were not enough to inhibit the IL-2 (interleukin-2) activation of peripheral blood lymphocytes. However the amount of PGE2 produced by approximately 1 x 10(7) of the glioblastoma cells can be assumed to suppress the generation of IL-2-induced killing activity against glioblastoma cells.
Authors:
Y Sawamura; A C Diserens; N de Tribolet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  9     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-02-01     Completed Date:  1991-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Brain Neoplasms / metabolism*
Culture Media
Dinoprostone / biosynthesis*,  physiology
Glioblastoma / metabolism*
Humans
Interleukin-2 / antagonists & inhibitors*
Killer Cells, Lymphokine-Activated / physiology*
Radioimmunoassay
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Culture Media; 0/Interleukin-2; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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