Document Detail


In vitro permeation studies of nanoemulsions containing ketoprofen as a model drug.
MedLine Citation:
PMID:  18712624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We prepared a nanoemulsion system with benzyl alcohol/ ethanol/Solutol/smash(R) HS 15 /water. Ketoprofen was used as a model drug in this study. The nanoemulsions of this system evidenced a high degree of stability. The droplet diameter did not change over a period of at least 3 months. The nanoemulsion containing 4% benzyl alcohol evidenced a permeation rate higher than was observed with the 1% and 2% nanoemulsions. Also the nanoemulsion containing 1% Solutol(R) HS 15 provided a permeation rate higher than was seen with the 2% and 4% nanoemulsions. All ketoprofen-loaded nanoemulsions enhanced the in vitro permeation rate through mouse skins as compared to the control.
Authors:
Beom Su Kim; Myoung Won; Kang Min Lee; Cheo Sang Kim
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug delivery     Volume:  15     ISSN:  1521-0464     ISO Abbreviation:  Drug Deliv     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9417471     Medline TA:  Drug Deliv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-9     Citation Subset:  IM    
Affiliation:
Laboratory of Enzyme Technology, College of Natural Science, Chonju, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  chemistry*,  metabolism
Benzyl Alcohol / chemistry
Chromatography, High Pressure Liquid
Drug Carriers / chemistry*
Drug Compounding
Drug Stability
Emulsions
Ethanol / chemistry
Ketoprofen / administration & dosage,  chemistry*,  metabolism
Male
Mice
Nanoparticles*
Particle Size
Permeability
Polyethylene Glycols / chemistry
Skin / metabolism*
Stearic Acids / chemistry
Water / chemistry
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Drug Carriers; 0/Emulsions; 0/Polyethylene Glycols; 0/Stearic Acids; 100-51-6/Benzyl Alcohol; 22071-15-4/Ketoprofen; 61909-81-7/Solutol HS 15; 64-17-5/Ethanol; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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