Document Detail


In vitro permeation of micronized and nanonized alaptide from semisolid formulations.
MedLine Citation:
PMID:  24453907     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name "alaptide," in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or regeneration of the injured skin. The above mentioned technological modifications influence the permeation of alaptide through artificial or biological membranes, such as PAMPA or skin. The permeation of micronized and nanonized form of alaptide formulated to various semisolid pharmaceutical compositions through full-thickness pig ear skin using a Franz cell has been investigated in detail. In general, it can be concluded that the nanonized alaptide permeated through the skin less than the micronized form; different observations were made for permeation through the PAMPA system, where the micronized form showed lower permeation than the nanonized alaptide.
Authors:
Radka Opatrilova; Aneta Cernikova; Lenka Coufalova; Jiri Dohnal; Josef Jampilek
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Publication Detail:
Type:  Journal Article     Date:  2013-12-18
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  2013     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-01-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  England    
Other Details:
Languages:  eng     Pagination:  787283     Citation Subset:  IM    
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