Document Detail

In vitro perfusion studies of single umbilical artery cords: the vasoactive effects of serotonin.
MedLine Citation:
PMID:  10203293     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To investigate the vascular resistance and the vasoactive effects of serotonin in arteries from single umbilical artery (SUA) cords. METHODS: The preparations were sampled from 10 patients with SUA cords. The control group (n=20) was matched according to gestational age, birth weight percentile, blood pressure and proteinuria. The arterial segments were perfused in vitro employing a constant perfusion rate and measuring alterations in perfusion pressure. Following an initial test with serotonin 10(-7) M the drug was administrated in stepwise increasing concentrations from 10(-10) to 10(-5) M. RESULTS: The vascular resistance was significantly reduced in the SUA group compared to the control group (p<0.01). In about half of the preparations in both groups serotonin 10(-7) M induced a transient pressure decrease followed by a larger pressure increase. The remaining arteries showed a monophasic pressure increase. The maximum constrictory response calculated in percent of the prestimulatory perfusion pressure was significantly increased (p<0.01) in the SUA compared to the control group, but non-significantly increased (p=0.073) when calculated in absolute values (mmHg). CONCLUSIONS: Arteries in SUA cords display reduced vascular resistance compared to arteries from normal cords in in vitro perfused preparations. The response pattern to serotonin was not altered, but the constrictory response might be increased in arteries from SUA cords.
G Haugen; N Moe
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  78     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-04-29     Completed Date:  1999-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  285-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, The National Hospital, University of Oslo, Norway.
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MeSH Terms
Serotonin / pharmacology*
Umbilical Arteries / abnormalities*,  drug effects
Umbilical Cord / blood supply*
Vascular Resistance / drug effects*,  physiology
Vasoconstriction / drug effects
Vasodilation / drug effects
Reg. No./Substance:

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