Document Detail


In vitro perfused, non-isolated small intestine: ontogeny of transmural hydraulic permeability.
MedLine Citation:
PMID:  565047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Net fluid flux and transmural hydrostatic hydraulic conductance (Lp) were measured in the rat ileum during postnatal ontogeny, utilizing a refined in vitro, capillary-perfused (non-isolated) preparation for free-flow studies. Volume absorption at low transmural pressure gradient (1-2 cmH2O) was 0.99 +/- 0.22 ml/g wet weight.hr in the mature ileum and 1.55 +/- 0.42 ml/g wwt.hr in the differentiating intestine. Hydrostatic hydraulic conductance of the mature ileum was 0.76 microliter/cm2.cm H2O.hr, indicating that normal hydrostatic pressure gradients are not important for modulation of intestinal absorption. In contrast, Lp was 3.82 microliter/cm2.cmH2O.hr in the differentiating ileu, suggesting a significant contribution of pressure-dependent solvent drag to isotonic solute absorption.
Authors:
J Wisser; M Horster
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  373     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-05-24     Completed Date:  1978-05-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Animals, Newborn / metabolism*
Biological Transport, Active
Hydrostatic Pressure
Ileum / metabolism*
Rats
Water / metabolism*
Chemical
Reg. No./Substance:
7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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