Document Detail


In vitro oocyte maturation for the treatment of infertility associated with polycystic ovarian syndrome: the French experience.
MedLine Citation:
PMID:  15528263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In vitro oocyte maturation (IVM) permits the use of immature oocytes in IVF. IVM does not require ovarian stimulation and so can be offered to patients at risk of ovarian hyperstimulation syndrome. METHODS: For this indication, we carried out 45 cycles of IVM in 33 women with polycystic ovarian syndrome (PCOS). RESULTS: A total of 509 cumulus-oocyte complexes was obtained; 276 (54.2%) oocytes matured in 24 h and 45 (8.8%) in 48 h. The normal fertilization (2PN) rate of oocytes matured in 24 and 48 h was 69.5 and 73.3% respectively. Among the 214 embryos obtained, 103 were transferred and 30 were frozen. Forty transfers were performed (2.5 embryos/transfer). Eleven women had a positive beta-hCG test (26.2% of pregnancies/puncture, 27.5% of pregnancies/transfer) and nine women had a clinical pregnancy (20.0% of pregnancies/puncture, 22.5% of pregnancies/transfer). Five babies have been born and one pregnancy is ongoing. Results of the clinical examination carried out at birth were normal. CONCLUSIONS: Our results show that IVM may be offered as an alternative to conventional IVF and to ovarian drilling in women with PCOS. The role of IVM in the therapeutic armamentarium for this condition should be further clarified.
Authors:
A Le Du; I J Kadoch; N Bourcigaux; S Doumerc; M-C Bourrier; N Chevalier; R Fanchin; R-C Chian; G Tachdjian; R Frydman; N Frydman
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2004-11-04
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  20     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-25     Completed Date:  2005-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  420-4     Citation Subset:  IM    
Affiliation:
Service de Biologie et Génétique de la Reproduction, Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cryopreservation
Embryo Culture Techniques
Embryo Transfer
Female
Fertilization in Vitro / methods*
France
Humans
Infertility, Female / etiology*,  therapy*
Ovary / cytology*,  physiology
Ovulation
Polycystic Ovary Syndrome / complications*
Pregnancy
Pregnancy Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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