Document Detail


In vitro and occupational induction of sister-chromatid exchanges in human lymphocytes with furfuryl alcohol and furfural.
MedLine Citation:
PMID:  4000179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sister-chromatid exchanges (SCEs) in human lymphocytes were studied using the FPG technique in order to determine the cytogenetic effect of furfural and furfuryl alcohol. The induction of SCEs was also investigated in workers occupationally exposed to these solvents that are commonly used in the manufacture of furoic resins. The results obtained from the in vitro treatments show that furfural increased the number of SCEs, while furfuryl alcohol did not. In exposed workers, neither of these solvents increased the spontaneous frequency of SCEs per metaphase.
Authors:
S Gomez-Arroyo; V Souza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  156     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-25     Completed Date:  1985-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cells, Cultured
Environmental Exposure
Furaldehyde / toxicity*
Furans / toxicity*
Humans
Lymphocytes / drug effects*
Mitosis / drug effects
Occupational Diseases / chemically induced
Polyploidy
Sister Chromatid Exchange / drug effects*
Chemical
Reg. No./Substance:
0/Furans; 98-00-0/furfuryl alcohol; 98-01-1/Furaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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