| In vitro naïve T cell proliferation failure predicts poor post-immunization responses to neoantigen, but not recall antigens, in HIV-infection. | |
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MedLine Citation:
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PMID: 20472504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immune reconstitution after HAART is incomplete, but no widely accepted method to quantify subclinical immune deficiency is available. We immunized 9 HIV-negative subjects and 29 HIV-infected patients with CD4>/=450 cells/microL and undetectable HIV RNA levels with 2 doses of diphtheria/tetanus toxoid (TT) and KLH, a presumed neoantigen. We quantified the response by lymphoproliferative assay, delayed-type hypersensitivity (DTH), and antibody titers up to 59days after enrollment. We assessed T cell proliferative capacity using anti-Vbeta3 and anti-Vbeta5 antibody stimulation, which we herein show induced predominant proliferation of naïve T cells. Subjects with detectable responses to KLH tended to exhibit greater proliferative responses to anti-Vbeta3/Vbeta5 stimulation; no such pattern was seen with response to TT. Several measures of in vitro T cell proliferative capacity correlated significantly with DTH and antibody responses to KLH, but not with TT responses; this association was independent of naïve T cell numbers. Our results indicate that naïve T cell proliferation predicts response to neo-, but not recall antigens, and suggest that it may be a meaningful reflection of in vivo immune competence in HIV-infected persons. |
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Authors:
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Benigno Rodriguez; Hernan Valdez; Christoph G Lange; Robert Asaad; Kathy Medvik; Scott F Sieg |
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Publication Detail:
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Type: In Vitro; Journal Article Date: 2010-05-15 |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: 136 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-06 Completed Date: 2010-08-30 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 400-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Case Western Reserve University Center for AIDS Research, Cleveland, OH 44106-5083, USA. rodriguez.benigno@clevelandactu.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibody Formation Antigens / administration & dosage Antiretroviral Therapy, Highly Active Case-Control Studies Cell Proliferation Female HIV Infections / drug therapy, immunology*, therapy Hemocyanin / administration & dosage Humans Hypersensitivity, Delayed Immunization Immunization Schedule Immunocompetence Lymphocyte Activation Male Middle Aged T-Lymphocytes / immunology*, pathology Tetanus Toxoid / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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P01 AI076174-01A1/AI/NIAID NIH HHS; P30 AI036219-15S18854/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Tetanus Toxoid; 0/keyhole-limpet hemocyanin; 9013-72-3/Hemocyanin |
| Comments/Corrections | |
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