Document Detail


In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract.
MedLine Citation:
PMID:  21034865     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The aim of the current study is to probe the anti-inflammatory/anti-allergic potential of seven phytoconstituents (andrographolide, neoandrographolide, isoandrographolide, andrograpanin, 14-deoxy-11,12-didehydroandrographolide, 7-O-methylwogonin and skullcapflavone-I) isolated from Andrographis paniculata (King of bitters) on the production of key inflammatory/allergic mediators (NO, PGE(2), IL-1 beta, IL-6, LTB(4), TXB(2) and histamine). The results demonstrated that andrographolide, isoandrographolide, 7-O-methylwogonin and skullcapflavone-I significantly inhibited LPS stimulated NO and PGE(2) release in J774A.1 macrophages. Andrographolide, isoandrographolide and 7-O-methylwogonin showed considerable inhibition of IL-1 beta production in LPS elicited macrophages. LPS induced IL-6 production was significantly inhibited by andrographolide, isoandrographolide and skullcapflavone-I in a concentration dependent manner. The results revealed that andrographolide, isoandrographolide and skullcapflavone-I significantly decreased TXB(2) release in A23187 activated HL-60 promyelocytic cells. Furthermore, the anti-allergic properties of the phytoconstituents was investigated on A23187 induced LTB(4) production (HL-60 cells) and histamine release (RBL-2H3 basophilic cells). The results showed that only skullcapflavone-I and 7-O-methylwogonin showed marked inhibitory effect on LTB(4) production, however, only 7-O-methylwogonin exerted dose-dependent inhibition towards histamine release. Therefore, this study indicates that some of these phytoconstituents exhibit potent anti-inflammatory/anti-allergic effects by modulating different inflammatory/allergic mediators. Hence, these phytoconstituents might provide useful phytomedical treatment against variety of inflammatory and allergic disorders.
Authors:
C V Chandrasekaran; P Thiyagarajan; H B Deepak; Amit Agarwal
Related Documents :
15765745 - A model of allergen-driven human airway contraction: beta2 pathway dysfunction without ...
20674565 - Comparison of the efficacy of tacrolimus and cyclosporine a in a murine model of dinitr...
8643265 - Role of allergy in eustachian tube blockage and otitis media with effusion: a review.
8466945 - Arachidonic acid metabolism of rat peritoneal macrophages after passive sensitization a...
16945135 - Bacterial lipopolysaccharide induces apoptosis in the trout ovary.
9414135 - Effects of tumor necrosis factor and pentoxifylline on icam-1 expression on human polym...
Publication Detail:
Type:  Journal Article     Date:  2010-10-27
Journal Detail:
Title:  International immunopharmacology     Volume:  11     ISSN:  1878-1705     ISO Abbreviation:  Int. Immunopharmacol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100965259     Medline TA:  Int Immunopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Six novel ATP7B mutations in Thai patients with Wilson disease.
Next Document:  The influence of a behavioral weight management program on disordered eating attitudes and behaviors...