Document Detail

In vitro model systems to study androgen receptor signaling in prostate cancer.
MedLine Citation:
PMID:  23447570     Owner:  NLM     Status:  MEDLINE    
Prostate cancer (PCa) is one of the most common causes of male cancer-related death in Western nations. The cellular response to androgens is mediated via the androgen receptor (AR), a ligand-inducible transcription factor whose dysregulation plays a key role during PCa development and progression following androgen deprivation therapy, the current mainstay systemic treatment for advanced PCa. Thus, a better understanding of AR signaling and new strategies to abrogate AR activity are essential for improved therapeutic intervention. Consequently, a large number of experimental cell culture models have been established to facilitate in vitro investigations into the role of AR signaling in PCa development and progression. These different model systems mimic distinct stages of this heterogeneous disease and exhibit differences with respect to AR expression/status and androgen responsiveness. Technological advances have facilitated the development of in vitro systems that more closely reflect the physiological setting, for example via the use of three-dimensional coculture to study the interaction of prostate epithelial cells with the stroma, endothelium, immune system and tissue matrix environment. This review provides an overview of the most commonly used in vitro cell models currently available to study AR signaling with particular focus on their use in addressing key questions relating to the development and progression of PCa. It is hoped that the continued development of in vitro models will provide more biologically relevant platforms for mechanistic studies, drug discovery and design ensuring a more rapid transfer of knowledge from the laboratory to the clinic.
Natalie Sampson; Hannes Neuwirt; Martin Puhr; Helmut Klocker; Iris E Eder
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-03-26
Journal Detail:
Title:  Endocrine-related cancer     Volume:  20     ISSN:  1479-6821     ISO Abbreviation:  Endocr. Relat. Cancer     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-27     Completed Date:  2013-09-13     Revised Date:  2014-06-09    
Medline Journal Info:
Nlm Unique ID:  9436481     Medline TA:  Endocr Relat Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  R49-64     Citation Subset:  IM    
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MeSH Terms
Cell Line
Cell Line, Tumor
Neoplastic Stem Cells
Prostatic Neoplasms / metabolism*
Receptors, Androgen / metabolism*
Signal Transduction
Grant Support
V 216-B13//Austrian Science Fund FWF
Reg. No./Substance:
0/Receptors, Androgen

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