Document Detail


In vitro model of stromal and epithelial immortalized endometriotic cells.
MedLine Citation:
PMID:  22109698     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Endometriosis is a relatively common chronic gynecologic disorder that usually presents with chronic pelvic pain or infertility. It results from implantation of endometrial tissue outside the uterine cavity. Despite its frequency and its impact on quality of life, the understanding of pathogenesis of endometriosis remains incomplete and its treatment remains controversial. In this work, we established a suitable in in vitro model system of immortalized human endometriotic cell line taking advantage of the human telomerase reverse transcriptase (hTERT). The results demonstrate that these cells retain the natural characteristics of endometrial cells in term of phenotype and of functional expression of estrogen and progesterone receptors, without chromosomal abnormalities. In conclusion, these cells are potentially useful as an experimental model to investigate endometriosis biology. J. Cell. Biochem. © 2011 Wiley Periodicals, Inc.
Authors:
Mariarosaria Boccellino; Lucio Quagliuolo; Annarita Verde; Raffaele La Porta; Stefania Crispi; Maria Teresa Piccolo; Antonio Vitiello; Alfonso Baldi; Pietro Giulio Signorile
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-22
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  -     ISSN:  1097-4644     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy.
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