Document Detail

In vitro mitral chordal cutting by high intensity focused ultrasound.
MedLine Citation:
PMID:  17988790     Owner:  NLM     Status:  MEDLINE    
Mitral regurgitation, when it arises from functional restriction of mitral leaflet closure, can be relieved by surgical cutting of the mitral tendineae chordae. We hypothesized that high intensity focused ultrasound (HIFU) might be useful as a noninvasive extracorporeal technique for cutting mitral chordae. As a pilot study to test this hypothesis, we examined the in vitro feasibility of using HIFU to cut calf mitral chordae with diameters from 0.2 to 1.6 mm. Sixty-seven percent of chordae were completely cut with HIFU, operated at 4.67 MHz and 45 W acoustic power, with up to 120 pulses of 0.3-s duration at 2-s intervals. Forty-five percent were completely cut when the pulse duration was reduced to 0.2 s. The average diameter of those chordae, which were completely cut, was significantly smaller than that of incompletely cut chordae (0.59 +/- 0.30 versus 1.14 +/- 0.30 mm with a pulse duration of 0.2 s, p < 0.0001; 0.68 +/- 0.29 versus 1.32 +/- 0.20 mm with a pulse duration of 0.3 s, p < 0.0001). For each pulse duration, the number of pulses required for complete cutting exhibited a strong positive correlation with the chordae diameter. In conclusion, in vitro feasibility of mitral chordal cutting by HIFU depended on the diameter of chordae but was controllable by HIFU settings. (E-mail:
Yukio Abe; Ryo Otsuka; Robert Muratore; Kana Fujikura; Kazue Okajima; Keiko Suzuki; Jie Wang; Charles Marboe; Andrew Kalisz; Jeffrey A Ketterling; Frederic L Lizzi; Shunichi Homma
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-11-07
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  34     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  400-5     Citation Subset:  IM    
Department of Medicine Cardiology Division, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
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MeSH Terms
Chordae Tendineae
Feasibility Studies
Mitral Valve / pathology,  ultrasonography
Mitral Valve Insufficiency / pathology,  therapy*
Models, Animal
Ultrasonic Therapy / instrumentation,  methods*
Grant Support

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