| In vitro methods of evaluating antithrombotics and thrombolytics. | |
| | |
MedLine Citation:
|
PMID: 20617413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Platelets play a crucial role in primary hemostasis by forming hemostatic plugs at sites of vascular injury. There is abundant evidence that platelets also play a pivotal role in the pathogenesis of arterial thrombotic disorders, including unstable angina (UA), myocardial infarction (MI), and stroke. The underlying pathophysiological mechanism of these processes has been recognized as the disruption or erosion of a vulnerable atherosclerotic plaque, leading to local platelet adhesion and subsequent formation of partially or completely occlusive platelet thrombi. A variety of methods have been used to assess platelet aggregation, blood coagulation, and the ex vivo and/or in vitro efficacy of platelet antagonists, anticoagulants, and thrombolytics. |
| | |
Authors:
|
Shaker A Mousa |
Related Documents
:
|
11153753 - Sildenafil citrate (viagra) does not exacerbate myocardial ischemia in canine models of... 6169823 - Beneficial effects of a new carbacyclin derivative, zk 36 374, in acute myocardial isch... 1396473 - Effects of ozone exposure on lipid metabolism in human alveolar macrophages. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Methods in molecular biology (Clifton, N.J.) Volume: 663 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-07-09 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 1-28 Citation Subset: IM |
Affiliation:
|
Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Coagulation / drug effects Blood Platelets / cytology, drug effects Cell Adhesion / drug effects Chromatography, Gel Collagen / metabolism Drug Evaluation, Preclinical / methods* Erythrocytes / cytology, metabolism Fibrinolytic Agents / pharmacology*, therapeutic use Flow Cytometry Humans Lasers Male Platelet Aggregation / drug effects Rats Rats, Sprague-Dawley Receptors, Fibrinogen / metabolism Rheology Thrombelastography / drug effects Thrombosis / drug therapy, physiopathology Viscosity |
| Chemical | |
Reg. No./Substance:
|
0/Fibrinolytic Agents; 0/Receptors, Fibrinogen; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Percutaneous mitral valve interventions: overview of new approaches.
Next Document: In vivo models for the evaluation of antithrombotics and thrombolytics.