Document Detail


In vitro methods of evaluating antithrombotics and thrombolytics.
MedLine Citation:
PMID:  20617413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Platelets play a crucial role in primary hemostasis by forming hemostatic plugs at sites of vascular injury. There is abundant evidence that platelets also play a pivotal role in the pathogenesis of arterial thrombotic disorders, including unstable angina (UA), myocardial infarction (MI), and stroke. The underlying pathophysiological mechanism of these processes has been recognized as the disruption or erosion of a vulnerable atherosclerotic plaque, leading to local platelet adhesion and subsequent formation of partially or completely occlusive platelet thrombi. A variety of methods have been used to assess platelet aggregation, blood coagulation, and the ex vivo and/or in vitro efficacy of platelet antagonists, anticoagulants, and thrombolytics.
Authors:
Shaker A Mousa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  663     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-09     Completed Date:  2010-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-28     Citation Subset:  IM    
Affiliation:
Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Coagulation / drug effects
Blood Platelets / cytology,  drug effects
Cell Adhesion / drug effects
Chromatography, Gel
Collagen / metabolism
Drug Evaluation, Preclinical / methods*
Erythrocytes / cytology,  metabolism
Fibrinolytic Agents / pharmacology*,  therapeutic use
Flow Cytometry
Humans
Lasers
Male
Platelet Aggregation / drug effects
Rats
Rats, Sprague-Dawley
Receptors, Fibrinogen / metabolism
Rheology
Thrombelastography / drug effects
Thrombosis / drug therapy,  physiopathology
Viscosity
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Receptors, Fibrinogen; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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