Document Detail


In vitro metabolism of phenylacetone, phenyl-2-butanone, and 3-methyl-1-phenyl-2-butanone by rabbit liver preparations.
MedLine Citation:
PMID:  28919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phenylacetone, phenyl-2-butanone, and 3-methyl-1-phenyl-2-butanone were incubated with rabbit liver 9000g supernatant fraction for 30 and 60 min to yield primarily the alcohols, plus small amounts of 1,2-glycols and ketols (2-one-1-ols). Phenylacetone incubations produced small amounts of benzoic acid, which was confirmed as a true metabolite by incubation of 2H5 (phenyl-labeled) phenylacetone and corresponding recovery of phenyl-labeled benzoic acid. No benzoic acid was detectable from incubations of phenyl-2-butanone and 3-methyl-1-phenyl-2-butanone. 3-Methyl-1-phenyl-2-butanone yielded eight metabolites in addition to the corresponding alcohol, and structures are proposed for some of these metabolic products.
Authors:
R C Kammerer; A K Cho; J Jonsson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug metabolism and disposition: the biological fate of chemicals     Volume:  6     ISSN:  0090-9556     ISO Abbreviation:  Drug Metab. Dispos.     Publication Date:    1978 Jul-Aug
Date Detail:
Created Date:  1978-11-22     Completed Date:  1978-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421550     Medline TA:  Drug Metab Dispos     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  396-402     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetone / analogs & derivatives*,  metabolism
Animals
Butanones / metabolism*
Chromatography, Gas
Liver / metabolism*
Male
Mass Spectrometry
Rabbits
Chemical
Reg. No./Substance:
0/Butanones; 67-64-1/Acetone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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