| In vitro metabolism of phenylacetone, phenyl-2-butanone, and 3-methyl-1-phenyl-2-butanone by rabbit liver preparations. | |
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MedLine Citation:
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PMID: 28919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phenylacetone, phenyl-2-butanone, and 3-methyl-1-phenyl-2-butanone were incubated with rabbit liver 9000g supernatant fraction for 30 and 60 min to yield primarily the alcohols, plus small amounts of 1,2-glycols and ketols (2-one-1-ols). Phenylacetone incubations produced small amounts of benzoic acid, which was confirmed as a true metabolite by incubation of 2H5 (phenyl-labeled) phenylacetone and corresponding recovery of phenyl-labeled benzoic acid. No benzoic acid was detectable from incubations of phenyl-2-butanone and 3-methyl-1-phenyl-2-butanone. 3-Methyl-1-phenyl-2-butanone yielded eight metabolites in addition to the corresponding alcohol, and structures are proposed for some of these metabolic products. |
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Authors:
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R C Kammerer; A K Cho; J Jonsson |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Drug metabolism and disposition: the biological fate of chemicals Volume: 6 ISSN: 0090-9556 ISO Abbreviation: Drug Metab. Dispos. Publication Date: 1978 Jul-Aug |
Date Detail:
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Created Date: 1978-11-22 Completed Date: 1978-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421550 Medline TA: Drug Metab Dispos Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 396-402 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetone
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analogs & derivatives*,
metabolism Animals Butanones / metabolism* Chromatography, Gas Liver / metabolism* Male Mass Spectrometry Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Butanones; 67-64-1/Acetone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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