| In vitro metabolism of 1-phenyl-2-(n-propylamino) propane (N-propylamphetamine) by rat liver homogenates. | |
| | |
MedLine Citation:
|
PMID: 11289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In vitro incubation of (+/-)-N-(n-propyl)amphetamine (NPA) with the 12000 g supernatant fraction of rat liver hmogenate resulted in the formation of two N-oxygenated products identified as N-hydroxy-1-phenyl-2(n-propylamino)propane and N-[(1-methyl-2-phenyl) ethyl]-1-propanamine N-oxide by g.l.c., g.l.c.-m.s. and t.l.c. Amphetamine, phenylacetone,... |
| | |
Authors:
|
R T Coutts; G W Dawson; A H Beckett |
Related Documents
:
|
8831979 - Carbocyclic analogues of d-ribose-5-phosphate: synthesis and behavior with 5-phosphorib... 17825439 - Motivated exploratory behaviour in the rat: the role of hippocampus and the histaminerg... 4390669 - Interaction between (plus or minus)-amphetamine and atropine on the rat cardiovascular ... 7919939 - Nmda-gaba interactions in an animal model of behaviour: a gating mechanism from motivat... 22321459 - Isolation-induced behavioural changes in a genetic animal model of depression. 9755509 - The representation of space and the hippocampus in rats, robots and humans. 7260599 - Neonatal capsaicin and thermal nociception: a paradox. 9445089 - Exposure to in utero irradiation produces disruption of radial glia in rats. 19163679 - Photosensitization reaction-induced electrical blockade in myocardial tissue. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: The Journal of pharmacy and pharmacology Volume: 28 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1976 Nov |
Date Detail:
|
Created Date: 1977-01-28 Completed Date: 1977-01-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 815-21 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amphetamines
/
metabolism* Animals Hydrogen-Ion Concentration Liver / metabolism* Methylcholanthrene / pharmacology Microsomes, Liver / drug effects, metabolism* Niacinamide / pharmacology Phenobarbital / pharmacology Rats |
| Chemical | |
Reg. No./Substance:
|
0/Amphetamines; 50-06-6/Phenobarbital; 56-49-5/Methylcholanthrene; 98-92-0/Niacinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A thin-layer chromatographic procedure for the assay of labelled noradrenaline and its metabolites i...
Next Document: A proposed mechanism for the biphasic vasoconstrictor responses to 5-hydroxytryptamine and methyserg...