Document Detail


In vitro lipid synthesis in human adipose tissue from three abdominal sites.
MedLine Citation:
PMID:  8214046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association between abdominal deposition of adipose tissue and morbidities accompanying obesity may be related to high rates of free fatty acid release from enlarged intra-abdominal stores. To investigate cellular mechanisms that might contribute to enlargement of intra-abdominal adipocytes, lipolysis, triacylglycerol (TG), and diacylglycerol (DG) synthesis from [14C]glucose was measured in abdominal subcutaneous, omental, and mesenteric adipose tissue from severely obese women and men. Subcutaneous adipose tissue from women showed the highest rates of TG synthesis compared with the intra-abdominal site, or any site in men. isoproterenol stimulated TG synthesis more in intra-abdominal than subcutaneous adipose tissue. In the basal state, intra-abdominal adipose tissue from both men and women showed rates of [14C]DG accumulation approximately 50% total [14C]acylglyceride accumulation, whereas, in subcutaneous adipose tissue, [14C]DG accumulation was approximately 25% of total. Basal lipolysis was lower in intra-abdominal than subcutaneous adipocytes. Stimulation of lipolysis reduced [14C]DG accumulation more in intra-abdominal than subcutaneous adipose tissue. Low rates of acylglyceride synthesis in intra-abdominal adipocytes may prevent accumulation of large intra-abdominal fat stores in women.
Authors:
N K Edens; S K Fried; J G Kral; J Hirsch; R L Leibel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  265     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-11-23     Completed Date:  1993-11-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E374-9     Citation Subset:  IM    
Affiliation:
Laboratory of Human Behavior and Metabolism, Rockefeller University, New York 10021.
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MeSH Terms
Descriptor/Qualifier:
Abdomen*
Adipose Tissue / metabolism*,  pathology
Adult
Diglycerides / biosynthesis
Female
Humans
Isoproterenol / pharmacology
Lipids / biosynthesis*
Lipolysis / drug effects
Male
Mesentery
Obesity / metabolism,  pathology
Omentum
Skin
Triglycerides / biosynthesis
Grant Support
ID/Acronym/Agency:
5P30DK-26687/DK/NIDDK NIH HHS; DK-30583/DK/NIDDK NIH HHS; GCRC MO1-RR-00102/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Diglycerides; 0/Lipids; 0/Triglycerides; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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