Document Detail


In vitro intestinal transport of vasopressin and its analogues.
MedLine Citation:
PMID:  3716836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intestinal transport of vasopressin and oxytocin and their analogues 1-deamino-8-D-arginine vasopressin and 1-deamino-2-tyrosine(omicron-ethyl)-oxytocin was studied in everted segments of rat jejunum. The transported peptides were identified by specific RIA methods and by quantitative high pressure liquid chromatography. Transport rates were highest for 1-deamino-8-D-arginine vasopressin and lowest for vasopressin. No transport maximum and no competitive inhibition could be demonstrated. The distribution volume of the peptides in the intestinal mucosa was found to be smaller than that of polyethylene glycol. It is concluded that peptides of this size are transferred across the intestinal mucosa by passive processes.
Authors:
H Vilhardt; S Lundin
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  126     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-07-01     Completed Date:  1986-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  601-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Chromatography, High Pressure Liquid
Deamino Arginine Vasopressin / metabolism
Intestinal Absorption*
Intestinal Mucosa / metabolism
Male
Oxytocin / analogs & derivatives,  metabolism*
Radioimmunoassay
Rats
Rats, Inbred Strains
Vasopressins / metabolism*
Chemical
Reg. No./Substance:
11000-17-2/Vasopressins; 16679-58-6/Deamino Arginine Vasopressin; 50-56-6/Oxytocin; 77648-79-4/oxytocin, 1-desamino-(O-Et-Tyr)(2)-

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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