| In vitro interactions of captopril with H2-receptor antagonists. | |
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MedLine Citation:
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PMID: 17416569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Captopril is effective in the treatment of hypertension of all grades of severity. H2-receptors antagonists block gastric acid secretion and some cardiovascular effects of histamine. In view of the fact that, simultaneous administration of both drugs may alter the antihypertensive effect of captopril, present paper deals with the in vitro availability studies of captopril in presence of commonly used H2-receptor antagonists like cimetidine, ranitidine and famotidine. In order to simulate various pH levels in GI tract and to find out the kinetics and energetics of captopril-H2-receptor antagonist interactions, these studies were carried out in buffers of pH 4, 7.4 and 9 at 37 degrees C and at elevated temperatures. These studies clearly indicate that most of the H2-receptor antagonists bind to captopril, forming charge-transfer complexes. As a result, the availability of captopril was affected by the concurrent administration of H2-receptor antagonists. Accordingly coadministration of both the drugs should be avoided. |
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Authors:
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Najma Sultana; M Saeed Arayne; Reeshanul Quraish |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 20 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-09 Completed Date: 2007-07-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 132-9 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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chemistry*,
metabolism Anti-Ulcer Agents / chemistry*, pharmacology Antihypertensive Agents / chemistry*, metabolism Captopril / chemistry*, metabolism Cimetidine / chemistry Drug Interactions Famotidine / chemistry Gastric Juice / chemistry Histamine H2 Antagonists / chemistry*, pharmacology Hydrogen-Ion Concentration Kinetics Models, Chemical Ranitidine / chemistry Solubility Temperature Thermodynamics |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Anti-Ulcer Agents; 0/Antihypertensive Agents; 0/Histamine H2 Antagonists; 51481-61-9/Cimetidine; 62571-86-2/Captopril; 66357-35-5/Ranitidine; 76824-35-6/Famotidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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