| In vitro interaction between psychotropic drugs and alcohol dehydrogenase activity. | |
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MedLine Citation:
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PMID: 2051344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of CNS-stimulating and -depressant drugs have been studied for their in vitro interaction with horse liver alcohol dehydrogenase (ADH) activity. The depressant drugs studied included barbital, phenobarbital, thiopental, nitrazepam, chlorpromazine, sulpiride, clomethiazole, Li2CO3, diazepam, phenytoin, ethosuximide, morphine, and codeine. The stimulant drugs were theophylline, caffeine, amphetamine, imipramine, chlorimipramine, amitriptyline, and tranylcypromine. The results were as follows. First, ADH activity was inhibited by the action of chlorpromazine, tranylcypromine, imipramine, chlorimipramine, amitriptyline, sulpiride, amphetamine, codeine, ethosuximide, morphine, clomethiazole, nitrazepam, Li2CO3, theophylline, and phenobarbital, in descending order of inhibitory effect. Second, inhibition followed by activation of ADH activity was observed for imipramine and chlorimipramine. Third, activation of ADH activity was observed for phenytoin. Finally, the following drugs were not seen to exert any effect on ADH activity: barbital, thiopental, diazepam, and caffeine. |
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Authors:
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M G Roig; F Bello; F J Burguillo; J M Cachaza; J F Kennedy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 80 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-07-22 Completed Date: 1991-07-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 267-70 Citation Subset: IM |
Affiliation:
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Departamento de Química Física, Facultad de Farmacia, Universidad de Salamanca, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Dehydrogenase
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antagonists & inhibitors*,
metabolism Animals Electrophoresis, Polyacrylamide Gel Enzyme Activation / drug effects Horses Liver / enzymology Oxidation-Reduction Proteins / analysis Psychotropic Drugs / pharmacology* Solutions Spectrophotometry, Ultraviolet |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 0/Psychotropic Drugs; 0/Solutions; EC 1.1.1.1/Alcohol Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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