Document Detail


In vitro inhibitory effects of disodium cromoglycate on ionic transports involved in sickle cell dehydration.
MedLine Citation:
PMID:  19401631     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The antiallergic and antiasthmatic drug disodium cromoglycate (DSCG) has also demonstrated an activity against sickle cell disease, but the mechanism of this action still remains unknown. METHODS: Na(+) and K(+) fluxes were studied in red cells obtained from 9 patients affected with sickle cell disease in the absence or in the presence of 1 mM of DSCG and deoxygenated under an N(2) flow during up to 24 h. RESULTS: A significant inhibiting effect of DSCG on the intracellular K(+) exit and the Na(+) entry was observed. CONCLUSION: These results demonstrate that DSCG partially inhibits the abnormal K(+) loss which is implicated in the dehydration of the sickle cell and the stimulation of sickling.
Authors:
Léonidas Bizumukama; Alina Ferster; Béatrice Gulbis; Alain Kumps; Frédéric Cotton
Publication Detail:
Type:  In Vitro; Journal Article     Date:  2009-04-25
Journal Detail:
Title:  Pharmacology     Volume:  83     ISSN:  1423-0313     ISO Abbreviation:  Pharmacology     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  318-22     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Laboratory of Medical Biochemistry, Institut de Pharmacie, Université Libre de Bruxelles, Bruxelles, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Anemia, Sickle Cell / blood*
Cromolyn Sodium / pharmacology*
Dehydration*
Hemoglobins / metabolism
Humans
Ion Transport / drug effects*
Oxygen / blood
Potassium / blood
Sodium / blood
Chemical
Reg. No./Substance:
0/Hemoglobins; 15826-37-6/Cromolyn Sodium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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