| In vitro inhibitory effect on porphyrinogen carboxylyase of liver extracts from TCDD treated mice. | |
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MedLine Citation:
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PMID: 6695412 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Marked inhibition of porphyrinogen carboxylyase was produced in vitro by cytosol fractions, deproteinized and free of porphyrins, obtained from livers of mice made porphyric by 9 weeks i.p. treatment with 25 micrograms/kg/week of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Inhibition was proportional to the amount of the fraction added, was increased by preincubation in the absence of the substrate and, once established, could not be reversed by dialysis. TCDD itself, added to the control enzyme in the incubation mixture, did not affect enzyme activity up to a concentration of 77 nM, which is 10 times higher than the liver TCDD concentration found after in vivo TCDD treatment. |
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Authors:
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L Cantoni; D dal Fiume; M Rizzardini; R Ruggieri |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology letters Volume: 20 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-03-15 Completed Date: 1984-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 211-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carboxy-Lyases / antagonists & inhibitors* Cytosol / drug effects, enzymology Decarboxylation Dioxins / pharmacology* Liver / drug effects, enzymology* Male Mice Mice, Inbred C57BL Tetrachlorodibenzodioxin / pharmacology* Uroporphyrinogens / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Dioxins; 0/Uroporphyrinogens; 1746-01-6/Tetrachlorodibenzodioxin; EC 4.1.1.-/Carboxy-Lyases; EC 4.1.1.-/porphyrinogen carboxy-lyase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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