| In vitro inhibition of low density lipoprotein carbamylation by vitamins, as an ameliorating atherosclerotic risk in uremic patients. | |
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MedLine Citation:
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PMID: 20156036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Previous studies have shown that the increase of carbamylated LDL (cLDL), a product of nonenzymatic modification of LDL in human serum by urea-derived cyanate, may cause cardiovascular complications in patients with chronic renal insufficiency. This study examined the inhibitory effect of ascorbic acid, alpha-tocopherol and lycopene on LDL carbamylation in an in vitro model system. METHODS: After isolation of LDL from plasma using an ultracentrifuge technique, cyanate was added to it and then LDL carbamylation was measured in both the absence and presence of ascorbic acid, alpha-tocopherol and/or lycopene by the colorimetric method at 530 nm. RESULTS: The findings indicated that these vitamins inhibit LDL carbamylation and the most effective vitamin of the three is lycopene. Moreover, the effect of lycopene on this process increased in the presence of ascorbic acid and alpha-tocopherol. CONCLUSION: This study indicated that ascorbic acid, alpha-tocopherol and lycopene with antioxidant activity can probably inhibit LDL carbamylation and therefore may have a role in ameliorating atherosclerotic risk of patients with kidney failure. However in vitro and in vivo investigations are required to confirm the exact effects of these vitamins on patients suffering from uremic disorders. |
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Authors:
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Mohammad Ali Ghaffari; Mehrnoosh Shanaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 70 ISSN: 1502-7686 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-19 Completed Date: 2010-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: England |
Other Details:
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Languages: eng Pagination: 122-7 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry, Cellular and Molecular Research Center & Physiology Research Center, Ahwaz Jundishapour University of Medical Sciences, Ahwaz, Iran. ghaffari@ajums.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ascorbic Acid / pharmacology Atherosclerosis / etiology, prevention & control* Carotenoids / pharmacology Citrulline / analogs & derivatives, analysis Cyanates / metabolism* Electrophoresis, Agar Gel Humans Lipoproteins, LDL / chemistry, metabolism* Male Protein Processing, Post-Translational / drug effects* Uremia / complications, metabolism* Vitamins / pharmacology* Young Adult alpha-Tocopherol / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cyanates; 0/Lipoproteins, LDL; 0/Vitamins; 0/carbamyl-LDL; 1190-49-4/homocitrulline; 36-88-4/Carotenoids; 372-75-8/Citrulline; 50-81-7/Ascorbic Acid; 502-65-8/lycopene; 59-02-9/alpha-Tocopherol; 590-28-3/potassium cyanate |
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